Management Change/Compensation Form 8 K

Item 5.02  Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On December 4, 2024, Annovis Bio, Inc. ("Annovis") appointed William Fricker, age 61, to serve as Chief Financial Officer on an interim basis. Mr. Fricker most recently served as Chief Financial Officer of NeuroTrauma Sciences from December 2023 to April 2024. Prior to NeuroTrauma Sciences, Mr. Fricker served as an independent contractor providing CFO services to biotech companies from September 2021 to November 2023. From November 2020 to August 2021, Mr. Fricker served as CFO for NRX Pharmaceuticals, taking the Company public in May of 2020. Mr. Fricker served as Chief Accounting Officer for Immunomedics from February 2018 to the sale of the Company to Gilead in October 2020. Mr. Fricker started his career at PriceWaterhouseCoopers and has held management positions as Bristol Myers Squibb, Johnson & Johnson and Tyco. Mr. Fricker graduated from Penn State University with a B.S. in Accounting and is a CPA (Inactive). There are no transactions between Mr. Fricker and Annovis of the type required to be disclosed by Item 404(a) of Regulation S-K.

Mr. Fricker is serving on a contract basis and is not a party to any employment agreement or similar arrangement with Annovis.