Material Agreement Form 8 K

Item 1.01 Entry into a Material Definitive Agreement.

On September 4, 2024, Shuttle Pharmaceuticals Holdings, Inc., a Delaware corporation (the "Company"), issued a $250,000 promissory note (the "Promissory Note") to the Company's CEO, Dr. Anatoly Dritschilo, in exchange for Dr. Dritschilo's loan of $250,000 to the Company. The Promissory Note accrues interest at 12% per annum and is repayable in 12 substantially equal installments over a period of one year.

The foregoing description of the Promissory Note does not purport to be complete and is qualified in its entirety by reference to the full text of the agreement, which is filed herewith as Exhibit 10.1.