Management Change/Compensation Form 8 K

On November 20, 2024, Karyopharm Therapeutics Inc. (the "Company") announced the appointment of Kristin Abate, the Company's Vice President, Accounting, Corporate Controller and Assistant Treasurer, as the Company's Vice President, Chief Accounting Officer, and Assistant Treasurer, effective November 20, 2024. Ms. Abate, who has also served as the Company's interim principal financial officer and interim principal accounting officer since November 6, 2024, has been designated as the Company's principal accounting officer, effective November 20, 2024. Ms. Abate will continue to serve as the Company's interim principal financial officer.

Ms. Abate, age 39, has over 15 years of experience in finance and has been employed by the Company since July 2019 in a variety of roles with increasing seniority. She served as Director, Accounting & Reporting from July 2019 to July 2020, Senior Director, Accounting & Reporting from July 2020 to May 2022, Executive Director of Accounting & Corporate Controller from May 2022 to August 2023, Vice President, Accounting & Corporate Controller from August 2023 to September 2024 and most recently, as Vice President, Accounting, Corporate Controller and Assistant Treasurer since September 2024. Prior to joining the Company, Ms. Abate worked in various roles as a public accountant from 2007 to July 2019 at PricewaterhouseCoopers LLP. Ms. Abate received a B.S. in Business Administration from Bryant University and a Masters of Science in Accountancy from Boston College and is a certified public accountant.

There are no family relationships between Ms. Abate and any director, executive officer or person nominated or chosen by the Company to become a director or executive officer of the Company. There are no transactions in which Ms. Abate has an interest requiring disclosure under Item 404(a) of Regulation S-K.