July: What's New from the Fertility and Sterility Family of Journals

July: What's New from the Fertility and Sterility Family of Journals

Here's a peek at this month's issues from our family of journals! As an ASRM Member, you can access all of our journals.

From Fertility and Sterility

A pilot study to investigate the clinically predictive values of copy number variations detected by next-generation sequencing of cell-free deoxyribonucleic acid in spent culture media

The objective of this study is to investigate the positive predictive value and false positive risk of copy number variations (CNV's) detected in cell-free deoxyribonucleic acid (DNA) from spent culture media for nonviable or aneuploid embryos. Whole chromosome abnormalities were associated with a high positive predictive value and significant RR for nonviability. Embryos associated with other CNVs had sustained implantation rates similar to those with no abnormalities detected. Further studies are required to validate the clinical applicability of niPGT-A.

From F&S Reports

Intracytoplasmic sperm injection versus conventional in vitro fertilization in unexplained infertility

This study compares cumulative live birth rate (CLBR) and cost-effectiveness of intracytoplasmic sperm injection (ICSI) vs. conventional in vitro fertilization (cIVF). Compared with cIVF alone, an estimated additional $11,011,500 was charged to patients for ICSI without genetic testing and $9,010,500 was charged to patients for ICSI with PGT-A over 2 years by Society for Assisted Reproductive Technology clinics. On the basis of total fertilization failure rates, 35 patients would require treatment with routine ICSI to avoid a single cycle of total fertilization failure with cIVF. Routine use of ICSI in unexplained infertility is not warranted due to the additional cost and lack of CLBR benefit.

From F&S Science

HMGA2 overexpression induces plasticity in myometrial cells and a transcriptomic profile more similar to that of uterine fibroids

This study looks at the possible role for HMGA2 overexpression in differentiated myometrial cells and its potential to induce a stem cell-like or dedifferentiating phenotype and drive fibroid development. The findings suggest that HMGA2 overexpression drives myometrial cells to dedifferentiate into a more plastic phenotype and provides evidence for an alternative mechanism for fibroid etiology, suggesting that fibroids may not only arise from a mutated stem cell but also from a mutated differentiated myometrial cell.

From F&S Reviews

Biomarkers to predict improvement of sperm parameters and hypogonadism after varicocele repair

The pursuit of noninvasive biomarkers has gained in significance for predicting improvement in fertility and assessing responses to varicocelectomy, offering opportunities for early intervention, minimizing unnecessary surgeries, and optimizing patient outcomes. This review consolidates current knowledge, underscores existing gaps, and outlines future research directions in refining diagnostic and therapeutic strategies for varicocele-related infertility.

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