04/11/2024 | Press release | Distributed by Public on 04/11/2024 09:57
Background: Research has shown that women whose immune systems are compromised (suppressed) are at increased risk for cell abnormalities in the cervix. These abnormalities are changes in the cells that may indicate the development of cervical cancer. Researchers from Australia's Monash University and University of Melbourne examined this issue in women with MS who had taken immune-regulating therapies.
The Study: The team analyzed information about women in Victoria, Australia who were diagnosed with MS; had screening for cervical abnormalities after MS diagnosis, and had no abnormalities before their MS diagnosis. They identified 248 women with MS, and separated them into two groups - those who had taken moderately effective MS therapies with longer safety track records those who had taken low-moderately effective therapies including platform injectables (interferon beta and glatiramer acetate) and an oral therapy (teriflunomide), or the more highly effective therapies that have more potential for adverse side effects and stronger impacts on the immune system (fingolimod, cladribine, dimethyl fumarate, natalizumab, ocrelizumab, rituximab, alemtuzumab). (Get comprehensive information on medications used in MS.)
Results: The team found that the risk of developing cervical abnormalities was more than 3 times higher in women taking highly effective medications. In both groups of women, they also found that the rates of vaccination for human papilloma virus (HPV) were low. HPV is a common infection that spreads through sexual contact and is a major cause of cervical cancer. An HPV vaccine, Gardasil®, is recommended for women in certain age groups. Gardasil is considered a safe vaccine for women who have MS.
Why does this matter? This study indicates that women with MS who have taken moderate-highly effective disease-modifying therapies are at greater risk of having cervical abnormalities than women who have taken low-moderately effective treatments. Although further study is needed, these findings are important because cervical abnormalities can be identified with proper screening and treated, thus preventing cervical cancer in most cases.
Get the facts about cervical cancer screening and how MS affects women