GoodRx Health

Seysara (sarecycline) is an oral medication that belongs to a class called tetracycline antibiotics. Like many other medications in its class, it can be helpful in treating acne by targeting the bacteria that causes it. If you have moderate-to-severe acne, Seysara is one option that your dermatologist may consider.

Certain factors can influence your Seysara dosage, such as your body weight. But what's a typical dose? Here's what you should know about Seysara dosages.

What's the typical Seysara dosage for adults?

Seysara comes as an oral tablet that you take by mouth once a day. It's available in three doses: 60 mg, 100 mg, and 150 mg. You can take Seysara with or without food, but taking your dose with food may help if it makes you feel nauseated. Since the tablet can irritate your esophagus, be sure to take it with enough fluid to swallow it whole.

The Seysara dosage for acne in adults is usually determined by body weight, as detailed in the chart below.

Keep in mind that your prescriber may have you take a Seysara dosage that's different from what's covered above.

Good to know: When taken together, products containing magnesium, aluminum, and calcium can bind to Seysara, potentially making it less effective. This is also the case for iron supplements. It's recommended to take Seysara 2 hours before or 6 hours after products with magnesium, aluminum, and calcium. For iron supplements, it's recommended to take Seysara 2 hours before or 4 hours after.

What's the typical Seysara dosage for children?

In addition to adults, Seysara is also approved for children ages 9 and older. Safety and effectiveness hasn't been established in younger children. What's more, tetracycline antibiotics can cause tooth discoloration in children younger than 8 years old.

The typical Seysara dosage for acne in children is also based on body weight. It's the same as it is for adults, as described in the table above.

Are there any dosage adjustments for medication interactions?

Seysara may interact with other medications you're taking. In some cases, this can influence your medication dose. This is usually because Seysara can prevent certain medications from being broken down, increasing the risk of side effects.

One example is digoxin, which requires regular monitoring to ensure that your dose is safe and effective. Seysara can increase digoxin (Lanoxin) levels in the body, increasing the risk of toxicity. If you start Seysara, your prescriber may lower your digoxin dose.

Seysara can also increase the risk of bleeding, especially if you take it with anticoagulants (blood thinners). One example is warfarin (Jantoven), which also requires careful monitoring and dosage adjustments. Your prescriber may want to monitor your blood work more often after you start Seysara. If needed, they'll adjust your warfarin dose. Tell them right away if you notice signs of bleeding, such as easy bruising. Get immediate medical attention if your bleeding is severe.

This is not the entire list of all medication interactions and dosage adjustments associated with Seysara. Be sure to share your medication list with your healthcare team. This helps them identify potential interactions and adjust your dosage in advance.

What happens if you miss a dose of Seysara?

If you miss a dose of Seysara, you should take the missed dose as soon as you remember. If you miss an entire day's dose, don't take two doses at once to make up for the dose you missed. Instead, skip the missed dose and resume your usual schedule.

Skipping doses or not taking Seysara consistently can lower its effectiveness or lead to bacterial resistance. Follow up with your dermatologist if you miss multiple doses of Seysara. Consider setting a daily alarm or using a medication reminder app to help you stay on track.

What should you do if you take too much Seysara?

If you take too much Seysara, contact your prescriber right away. They will assess if the dose you've taken warrants further evaluation. It's possible that taking too much Seysara may result in a higher likelihood of side effects, such as nausea, headaches, and dizziness.

You can also contact Poison Control at 1-800-222-1222 for guidance. If you have any symptoms that feel life-threatening, call 911 or go to the ER.

How to save on Seysara

There are ways to save on Seysara, which is available only as a brand-name medication. If you're eligible, you could pay as little as $35 for your prescription with a manufacturer copay card. If your insurance doesn't cover Seysara, you could pay $65 to $175 with the card, depending on the pharmacy.

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