08/26/2024 | Press release | Distributed by Public on 08/26/2024 03:17
Research Highlights:
Embargoed until 4 a.m. CT/5 a.m. ET, Monday, Aug. 26, 2024
DALLAS, Aug. 26, 2024 - Among people who had aneurysms (weakened areas in brain blood vessels), the risk of developing a mental health condition was higher than among peers without an aneurysm. The highest risk was seen in patients younger than age 40, according to research published today in Stroke, the peer-reviewed scientific journal of the American Stroke Association, a division of the American Heart Association.
An unruptured intracranial aneurysm occurs when the wall of a blood vessel in the brain becomes weak and bulges out, posing a potential risk of future rupture and life-threatening bleeding in the brain.
"As a neurosurgeon who treats cerebral aneurysms, I often see people who do not undergo surgery yet feel fear and/or anxiety about their condition before each imaging or screening test to monitor their condition. Even when it is medically judged and explained that follow-up observation is the best course for their aneurysm rather than surgery, they still worry about the very slim chance of developing a fatal brain bleed," said study co-author Na-Rae Yang, M.D., Ph.D., an assistant professor of neurosurgery in the department of neurosurgery at Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine in Seoul, South Korea.
"This study did not specifically target brain aneurysms that were small enough not to require treatment and had a low probability of rupture. We included all diagnosed, untreated brain aneurysms that were being followed," Yang said. "The reason for not treating and only following up may be that the aneurysm is small and unlikely to rupture, making treatment unnecessary. However, the decision is likely based on various circumstances, including the patient's overall condition, and such specific reasons were not captured in this study group."
While other studies have observed patterns of stress and anxiety in patients living with an aneurysm diagnosis, the researchers said this is one of the first large studies to estimate the risk of a mental health condition after aneurysm diagnosis.
In this study, researchers examined data from the National Health Information Database in South Korea, which includes over 20 years (2004 to 2024) of health data for more than 85,000 people who received care from hospitals, clinics and pharmacies throughout the country. It is one of the world's largest and most comprehensive health information databases. More than six months after diagnosis with an aneurysm, researchers compared how many people developed a mental health condition, such as anxiety, stress, depression, bipolar and eating disorders, insomnia and alcohol or drug misuse. They then compared them to the rate of mental health condition diagnoses among similar adults without aneurysm who received care for an upper respiratory infection.
The analysis took place over a 10-year period and found, when compared to people without an aneurysm:
"Our finding of a higher rate of a severe mental health condition in younger adults with aneurysm underscores the significant psychological burden for this group of patients who may already be dealing with other life stressors, such as building their career and/or raising a family," Yang said. "This elevated rate of mental health conditions suggests that younger people might be particularly vulnerable, highlighting the need for targeted mental health support and interventions for this age group. This includes providing clear explanations and tailoring treatment decisions for each person," Yang said.
An aneurysm may be diagnosed when a person has imaging (such as a CT scan or MRI) to evaluate neurological symptoms (such as a headache or vision changes), or it can be discovered by chance if imaging is done for an unrelated issue.
Study limitations include that the analysis was based on diagnostic and prescription codes in a national database, which may be imprecise and may not reflect the nuances of individual patient care and mental health status. In addition, the specific size and location of aneurysms were not considered. This study design highlights a possible association but cannot establish a cause-and-effect relationship between an aneurysm diagnosis and later mental health status. This study population was from South Korea, so the findings may not be consistent with populations in other countries.
Study details, background or design:
Co-authors, disclosures and funding sources are listed in the manuscript.
Studies published in the American Heart Association's scientific journals are peer-reviewed. The statements and conclusions in each manuscript are solely those of the study authors and do not necessarily reflect the Association's policy or position. The Association makes no representation or guarantee as to their accuracy or reliability. The Association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and biotech companies, device manufacturers and health insurance providers and the Association's overall financial information are available here.
Additional Resources:
###
About the American Stroke Association
The American Stroke Association is devoted to saving people from stroke - the No. 2 cause of death in the world and a leading cause of serious disability. We team with millions of volunteers to fund innovative research, fight for stronger public health policies and provide lifesaving tools and information to prevent and treat stroke. The Dallas-based association officially launched in 1998 as a division of the American Heart Association. To learn more or to get involved, call 1-888-4STROKE or visit stroke.org. Follow us on Facebook, X.
For Media Inquiries and AHA/ASA Expert Perspective: 214-706-1173
Karen Astle: [email protected]
For Public Inquiries: 1-800-AHA-USA1 (242-8721)
heart.org and stroke.org