Management Change/Compensation Form 8 K

Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

Effective September 16, 2024, Dr. Jeffrey Miller ceased serving as the Registrant's Consulting Chief Medical Officer and Consulting Chief Scientific Officer and commenced service as the Registrant's Consulting Senior Medical Director. Dr. Miller's title change is commensurate with his role with the Registrant and is responsive to a request from the University of Minnesota, Dr. Miller's employer, to align with the University's policies regarding conflicts of interest given the impending conduct of the Phase I clinical trial of the Registrant's GTB-3650 compound at the University.