Weight management drug does not increase risk of depression or suicidal behavior

Taking the weight loss medication semaglutide did not increase the risk of depressive symptoms, suicidal thoughts, or suicidal behavior in persons without known major mental health disorders, according to a new study led by researchers from the Perelman School of Medicine, published in JAMA Internal Medicine.

Semaglutide has emerged as a significant advancement in the field of weight management. Initially developed as a treatment for Type 2 diabetes, the drug gained widespread attention after clinical trialsshowed it reduced baseline body weight by approximately 10%-15%. Weekly injectable medications like semaglutide have become a popular option for health care providers to prescribe for patients. As many as 5 million Americans were prescribed semaglutide in 2023, with nearly four in ten taking it for weight management.

The new study, led by Thomas Wadden, a professor of psychology in psychiatry and the former director of Penn's Center for Weight and Eating Disorders, analyzed data from over 3,500 participants across four major clinical trials.

"The STEP trials provide strong evidence that semaglutide 2.4 mg reduces body weight and improves numerous health complications associated with obesity. Our new analyses provide assurance that the medication, when taken by individuals who are free of significant mental health concerns, does not increase the risk of depression, suicidal thoughts, or suicidal behavior," Wadden says.

This story is by Matt Toal. Read more at Penn Medicine News.