Management Change/Compensation Form 8 K

As previously reported on the Current Report on Form 8-Kfiled by Crinetics Pharmaceuticals, Inc. (the "Company") on September 17, 2024, James Hassard ceased serving as the Chief Operating Officer of the Company, effective October 14, 2024. On October 10, 2024, the Company entered into a Consulting Agreement (the "Consulting Agreement") with Mr. Hassard, pursuant to which Mr. Hassard agreed to provide to the Company up to 20 hours per month of certain services described therein relating to commercial activities and launch preparations related to the Company's investigational medicinal products (the "Services"), effective October 15, 2024 through January 15, 2025. Pursuant to the Consulting Agreement, Mr. Hassard will receive compensation of $200 per hour as well as reimbursement for reasonable travel and out-of-pocketexpenses incurred in performing the Services.

In addition, on October 10, 2024, the Company entered into a Separation and Release Agreement with Mr. Hassard (the "Separation Agreement"), pursuant to which the Company agreed to provide Mr. Hassard with the payments and benefits associated with a termination without cause, as set forth in the Employment Agreement, dated February 16, 2022, between the Company and Mr. Hassard (the "Employment Agreement"). In accordance with the terms of the Employment Agreement, the Consulting Agreement, the Separation and Release Agreement, the Company's 2018 Incentive Award Plan and the applicable award agreements thereunder, Mr. Hassard's outstanding equity awards will continue to vest through January 15, 2025.

The foregoing descriptions of the Consulting Agreement and the Separation Agreement are not complete and are qualified in their entirety by reference to the full text of the Consulting Agreement and the Separation Agreement, respectively, copies of which are filed as Exhibit 10.1 and Exhibit 10.2, respectively, hereto and are incorporated by reference herein.