07/08/2024 | News release | Distributed by Public on 07/08/2024 09:03
Osteoarthritis - a degenerative joint disease - can be challenging to live with. It causes pain and stiffness, making it difficult to go about your daily life. Virtually no one is immune to it as they get older, since it's caused by cartilage wearing down over the years, says Ramsey Shehab, M.D., a sports medicine physician at Henry Ford Health.
"Age is the greatest risk factor for osteoarthritis, but genetics and getting injured at a young age can also play into when someone will develop osteoarthritis - and how severe it will be," says Dr. Shehab.
That said, a recent study using mice found that a loss of a stem cell called the Gremlin 1 gene - which aids skeleton formation - may also play a role in osteoarthritis, suggesting the joint disease is due to more than structural wear and tear. Researchers from the University of Adelaide in Australia found that stem cell therapy to promote the production of Gremlin 1 cells made the mice's cartilage grow thicker.
But Dr. Shehab maintains a healthy dose of skepticism - at least for now. "There are so many mice studies. The problem is finding value in them," he says. "Taking these results from an animal to human study is a long shot. It's going to take much more research to see whether stem cell therapy to replace this gene will actually be a treatment for osteoarthritis."
Until then, Dr. Shehab says there are several ways to help manage symptoms of osteoarthritis:
The only cure right now for osteoarthritis is joint replacement surgery, which is usually an option after you've cycled through the above, lesser invasive options to manage symptoms.
"While some people are wary of joint replacement surgery, we have great technology that makes joint replacements longer lasting and feel more like natural joints," says Dr. Shehab. "It can really be life changing."
Reviewed by Ramsey Shehab, M.D., deputy chief of sports medicine at Henry Ford Health. He sees patients at the Henry Ford Center for Athletic Medicine, Henry Ford Medical Center - Troy and Henry Ford Medical Center - Bloomfield Township.