A Non-Coding Oligonucleotide Recruits Cutaneous CD11b+ Cells that Inhibit Thelper Responses and Prom

Kamal et.al. elucidated the immunoregulatory role of an oligonucleotide (ssON) that was found to recruit cutaneous immunoregulatory antigen-presenting cells (APCs) with increased immune checkpoint protein expression. Functional T-cell assays revealed that such immunoregulatory APCs inhibited T-helper cell responses and promoted CD4+FoxP3+Tregs. This study envisions the use of ssON as therapeutic for rebalancing overactive T-helper cell responses in the skin.