11 Suboxone Side Effects to Know About

Suboxoneis a combination medication that treatsopioid use disorder(OUD). It contains two medications: buprenorphine and naloxone. Buprenorphine reduces withdrawal symptoms and cravings, while naloxone is added to lower the potential for misuse. Suboxone is considered one of themost effective treatments for OUD.

It's normal to have questions about the risks associated with Suboxone. Here, we'll discuss in detail 11 Suboxone side effects and risks to consider if you're prescribed the medication.

Note: Suboxone and Zubsolv are brand-name buprenorphine / naloxone sublingual products. Both brand-name products are available as generic medications. In this article, we'll refer to buprenorphine / naloxone products collectively as Suboxone, since this medication is well known.

EXPERT PICKS: WHAT TO READ NEXT

• The best treatment for opioid use disorder (OUD):A treatment plan that combines medication and therapy, called medication for opioid use disorder (MOUD), is thegold standardfor treating OUD.
• How does Suboxone work?Learn how thispartial opioid agonisttreats OUD.
• Comparing first-choice medications for OUD:Learn about thedifferences between Suboxone and methadone(Methadose) - the most commonly used, and most studied, medications for treating OUD.

Suboxone side effects at a glance

Most Suboxone side effects are due to the buprenorphine component. In fact,very littlenaloxone is absorbed by the body when it's taken as directed. Naloxone is added to reduce the potential for someone to misuse Suboxone. However, there's somedebateas to whether naloxone actually has the ability to do this.

Some of the morecommonSuboxoneside effectsare:

• Mouth irritation, burning, or numbness
• Headaches
• Body aches and pains
• Drowsiness
• Dizziness
• Mental impairment
• Sweating
• Nausea and vomiting
• Constipation

Serious Suboxone side effects include:

• Dental problems
• Very low blood pressure
• Low adrenal hormone levels
• Heart rhythm problems
• Liver damage
• Misuse
• Opioid withdrawal symptoms
• Overdose
• Withdrawal in newborns who were exposed to Suboxone in the womb
• Extreme drowsiness leading to slowed breathing, accidents, or injury

Despite its potential side effects, Suboxone is usually well tolerated and the benefits generally outweigh the risks.

1. Mouth-related problems

Suboxone is dissolved under the tongue. This can cause discomfort, including a burning sensation and numbness in the mouth. More seriously, the FDA has issued awarningabout severe dental problems related to Suboxone. These potential problems include cavities, mouth infections, and even tooth loss.

You can take steps to reduce your risk for dental issues related to Suboxone, such as:

• After the tablet or film has fully dissolved, take a large sip of water. Swish it gently around your mouth, then swallow. This keeps Suboxone from staying in your mouth.
• Wait at least 1 hour before brushing your teeth to prevent tooth damage.
• Schedule regular checkups with your dentist during treatment. This will help you catch any problems before they worsen.

2. Headaches

Headachesare the most common Suboxone side effect. General aches and pains are also often reported. If you experience headaches with Suboxone, consider trying somebasic strategiesfor minimizing them, like drinking enough water, exercising, and doing breathing exercises or meditation. You can also talk to your pharmacist about over-the-counter (OTC) pain medications, such asacetaminophen(Tylenol) oribuprofen(Advil).

If you have headaches that are persistent or impact your daily life, let your prescriber know. They may recommend prescription headache medications.

3. Drowsiness and Dizziness

Suboxone can cause drowsiness and dizziness. So it's recommended to avoid driving and doing other activities that require alertness, especially when you first start taking Suboxone or after a dosage increase. Once you know how Suboxone affects you, you and your prescriber can decide if it's safe to resume these activities.

Most peopledevelop a toleranceto these side effects over time. But if you continue to experience drowsiness or dizziness, talk with your prescriber. Managing these side effects is particularly important forolder adults, who are more susceptible to injuries from falls.

Keep in mind that dizziness can also be a sign of low blood pressure, heart rhythm problems, or adrenal insufficiency. We will discuss these potential side effects more below.

4. Nausea and vomiting

Nausea, vomiting, and an upset stomach can all happen with Suboxone. This is one reason it's important to take Suboxone correctly.

Suboxone tablets and films should be placed under the tongue until fully dissolved. The films can also be placed against the inside of the cheek until fully dissolved. Neither formulation should be chewed or swallowed whole. Taking Suboxone correctly will help you get the most from the medication and help prevent nausea.

If you're taking Suboxone correctly but still experiencing nausea, talk to your pharmacist about whether there areOTC nausea medicationsthat could be good options for you.

5. Constipation

Constipation is a common Suboxone side effect. This is a common side effect of most opioids, and buprenorphine is considered a partial opioid as it binds to opioidreceptors. Since it binds to these receptors, we see this side effect occur with Suboxone, too.

Unfortunately, constipation from Suboxonedoesn't always go awayon its own. You may experience this side effect the whole time you're taking Suboxone. And lifestyle changes and medications may be needed to prevent or manage it.

Staying hydrated, eatingfiber-rich foods, andexercising regularlycan help with constipation.OTC laxativescan also help, but some are better than others for Suboxone-induced constipation. Common options includedocusate(Colace) andsenna(Senokot, Ex-Lax). Talk to your pharmacist about which laxatives they recommend.

6. Low blood pressure

Suboxone can causeorthostatic hypotension. This is a drop in blood pressure that occurs when a person changes positions, like when going from seated to standing or getting out of bed. It could cause you to feel dizzy or light-headed, putting you at risk forfalls and injuries.

Change positions slowly while taking Suboxone, especially when you first start taking it or if your dosage is increased. If you have symptoms that feel severe, speak to a healthcare professional as soon as possible. Dizziness can also be a sign of more rare Suboxone side effects likearrhythmias(abnormal heartbeats), andadrenal insufficiency(when the adrenal glands don't produce enough hormones).

7. Abnormal heartbeat

Suboxone can raise your risk oflong QT syndrome. Developing long QT syndrome is more likely if you already have heart problems or are taking othermedications that also cause this side effect.

Long QT syndrome doesn't always cause noticeable symptoms, but you may experience dizziness or heart palpitations. In severe cases, it can lead totorsades de pointes, a life-threatening arrhythmia. If you experience dizziness or heart palpitations, let your prescriber know immediately. If you faint or your symptoms feel severe, seek emergency care.

Be sure your healthcare team has your currentmedication listand is aware of your full medical history before starting treatment with Suboxone. They can help you check for possible drug interactions that may increase your risk of heart problems and assess your other health conditions, if needed.

8. Liver damage

There have been reports of liver damage in people taking Suboxone. Though, it's not clear if the damage was caused by Suboxone itself or if other factors, like undiagnosed liver disease orviral hepatitis, were to blame.

Your prescriber will check yourliver enzyme levelsbefore you start taking Suboxone and during treatment. It's possible for the medication to cause mild liver enzyme elevations. In most cases, this doesn't cause major problems and improves over time. If your levels are significantly elevated, however, Suboxone may not be the best option for you.

9. Withdrawal

Opioid withdrawalcan occur if your body becomesdependenton having opioids in your system and you stop taking them or reduce your dosage too quickly. Examples of opioid withdrawal symptoms include sweating, nausea, and diarrhea. Insomnia, anxiety, and irritability can also occur. Opioid withdrawal is rarely life-threatening, though it can be extremely uncomfortable.

There are two reasons you could experience opioid withdrawal with Suboxone:

1. If you take a Suboxone dose too soon after your last opioid dose:Suboxone should be taken several hours after your last opioid dose because it canblockthe effects of typical opioids. It's usuallyrecommended to waitat least 12 hours after receiving a short-acting opioid or at least 24 hours after receiving a long-acting opioid before taking Suboxone.
2. If you stop taking Suboxone abruptly or reduce your dosage too quickly:If you need to stop taking Suboxone, your prescriber will help you come up with a plan to taper off the medication over time. This may take several months or longer.

Although Suboxone can cause withdrawal symptoms for some people, it helpspreventwithdrawal for most people who stop taking opioids. In fact, when compared to a placebo - a pill that doesn't contain any medication - Suboxone is more effective at preventing opioid withdrawal.

It's also important to note thatnewbornswho were exposed to Suboxone in the womb can experience withdrawal symptoms. So let your prescriber know if you're pregnant before starting treatment with Suboxone. Although Suboxone is considered afirst-choice medicationfor OUD during pregnancy, your healthcare team may need to monitor your baby more closely after you give birth.

10. Misuse

Suboxone is acontrolled substance. This means that it carries a risk of dependence and misuse. But Suboxone is a Schedule 3 controlled substance, so it is less likely to cause misuse than Schedule 1 or 2 medications, like opioids.

Be sure to take Suboxone exactly as prescribed to help minimize your risk for misuse. If it doesn't feel like the medication is helping with cravings or withdrawal symptoms, talk to your prescriber, as they may recommend increasing your dosage. But don't make changes to your dosage without talking to them first. Self-medicating with extra medication or other substances can lead to dangerous side effects, like trouble breathing or overdose.

11. Overdose

Though rare, Suboxone can cause anoverdose. This is more likely if you take too much Suboxone or combine it with medications likebenzodiazepines, otheropioids, or alcohol. These substances can also affect your breathing, making an overdose from Suboxone more likely.

Besides slowed breathing, symptoms of an overdose include having pinpoint pupils, being unable to speak or respond to questions, and having bluish skin, especially on the lips and fingertips. If you think you're witnessing an overdose, administernaloxone(Narcan, Zimhi) ornalmefene(Opvee, Zurnai) if you have it. These medications canquickly reverse the effectsof an opioid overdose and be life-saving.Narcan nasal sprayis available OTC.

It's a good idea to carry naloxone or nalmefene on you at all times if you or a loved one takes Suboxone or opioids. Additionally, keep Suboxone stored in a safe location away from other people's reach, especially children. An overdose can occur if someone who isn't used to having opioids in their system ingests Suboxone.

It's also important to note that, over time, Suboxonelowers your toleranceto opioids. So if you start taking opioids again, lower dosages can cause an overdose.

Good to know:Although Suboxone contains naloxone, itcannot be usedto rescue someone from an overdose. Only injectable naloxone or naloxone nasal spray products can reverse an overdose. Learn how to give naloxone withthis GoodRx Health article.

h2]:mt-0
[&h2]:mb-[12px]
[&h2]:font-header-m
sm:[&h2]:font-header-l
[&p:first-of-type]:mt-0
[&ul:first-of-type]:mt-0
[&ol:first-of-type]:mt-0
[&*:last-child]:mb-0
[&*:last-childli:last-child]:mb-0
" data-qa="ContentCalloutH2Title" The bottom line

Suboxone is a first-choice medication for treating opioid use disorder. Common side effects include mouth irritation, headaches, and nausea. Constipation, dizziness, and opioid withdrawal symptoms may also occur.

Serious risks include liver damage, misuse, and overdose. However, the benefits of Suboxone treatment very often outweigh the risks associated with the medication.

Public link

Please use the above public link if you want to share this noodl on another website.