Material Agreement Form 8 K

Item 1.01

Entry into Material Definitive Agreements.

Exclusive License and Collaboration Agreement

On November 25, 2024, Sarepta Therapeutics, Inc. ("Sarepta") and Arrowhead Pharmaceuticals, Inc. ("Arrowhead") entered into an Exclusive License and Collaboration Agreement (the "Collaboration Agreement") pursuant to which Arrowhead granted Sarepta an exclusive license under certain of Arrowhead's intellectual property rights to develop, manufacture, commercialize, and otherwise exploit the lead candidate (and all backup candidates) for four clinical programs (the "Clinical Programs") and three pre-clinicalprograms (the "Pre-ClinicalPrograms"). The Clinical Programs are for targeted siRNA therapies directed to (a) DUX4 for the treatment of facioscapulohumeral muscular dystrophy, (b) DMPK for the treatment of type 1 myotonic dystrophy, (c) ATXN2 for the treatment of ataxias, and (d) MMP7 for the treatment of idiopathic pulmonary fibrosis. The pre-clinicalprograms are for targeted siRNA therapies directed to (a) ATXN1 for the treatment of ataxias, (b) ATXN3 for the treatment of ataxias, and (c) HTT for the treatment of Huntington's Disease. Sarepta and Arrowhead will also collaborate on the discovery and development of compounds that are directed to six targets to be selected by Sarepta during the term (each a "Discovery Program," and together with the Clinical Programs and Pre-ClinicalPrograms, the "Programs"). The selection of targets will be subject to certain restrictions set forth in the Collaboration Agreement. If a Discovery Program target is deemed futile, then Sarepta will have the right to substitute any such target up to two times.

Exclusivity

Except for its performance of activities under the Collaboration Agreement, Arrowhead may not perform any research, development, or commercialization activities with respect to any compounds or products (a) directed to any targets that are the subject of activities under the Collaboration Agreement, (b) for the treatment of spinocerebellar ataxias until the ATXN1 Program, ATXN2 Program, and ATXN3 Program have all terminated, or (c) directed to a list of reserved skeletal muscle targets for five years, provided that two of the reserved skeletal muscles will be subject to an additional two years of exclusivity.

Development, Manufacturing, and Commercialization

Arrowhead will conduct development activities with respect to the Programs under the Collaboration Agreement pursuant to agreed-upon development plans. At pre-determinedtransition points for each Program, Arrowhead will transfer development responsibility to Sarepta. Sarepta will then perform all development activities in furtherance of obtaining and maintaining regulatory approvals for licensed products throughout the world. Sarepta will reimburse Arrowhead for certain pre-determineddevelopment activities for the Clinical Programs. Each party is responsible for the costs and expenses of other development activities under the Collaboration Agreement.

Arrowhead will complete all manufacturing activities necessary for Arrowhead's development activities for each Program. Arrowhead will also provide clinical supply of licensed compounds and licensed products for all Programs under the Collaboration and commercial supply of licensed compounds and licensed products for the Clinical Programs. Sarepta and Arrowhead will determine at a later date whether Arrowhead will provide commercial supply of licensed compounds and licensed products for the Preclinical Programs and Discovery Programs. Upon the occurrence of certain conditions, Arrowhead will transfer control of manufacturing and supply to Sarepta.

Sarepta will have the sole right to commercialize licensed products throughout the world.

Governance

The exploitation of licensed compounds and licensed products will be governed by a series of committees established to facilitate transition and collaboration between the parties with respect to development and manufacturing of such products.

Financial Terms

At closing, Sarepta will pay Arrowhead an upfront payment of $500 million in cash. Arrowhead has the potential to receive $300.0 million in near-term payments associated with the continued enrollment of certain cohorts of a Phase 1/2 study. Additionally, Arrowhead is eligible to receive up to $250 million in annual fees and, for each of the Programs, Arrowhead is eligible to receive development milestone payments between $110.0 million and $180.0 million per Program and sales milestone payments between $500.0 million and $700.0 million per Program from Sarepta.

In addition, the Collaboration Agreement provides that Sarepta will pay Arrowhead tiered royalties on annual net sales of all licensed products for a given Program, up to the low double digits.

Term; Termination

Unless earlier terminated as described below, the Collaboration Agreement will continue on a licensed product-by-licensedproduct and country-by-countrybasis, until the expiration of the royalty term for such licensed product in such country. The Collaboration Agreement includes a customary royalty term.

Either party may terminate the Collaboration Agreement for the other party's material breach if such breach is not cured within a specified cure period.

Sarepta may terminate the Collaboration Agreement for convenience, in its entirety or on a licensed product-by-licensedproduct and region-by-regionbasis. If there is a clinical trial failure of the ongoing clinical trial for ARO-DM1,then, at its election, Sarepta may terminate the Collaboration Agreement with respect to either the DM1 Program or ARO-DM1.

The closing of the transaction contemplated by the Collaboration Agreement and the Stock Purchase Agreement (as defined below) is subject to the expiration or termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 and other customary conditions.

The foregoing description of the terms of the Collaboration Agreement is not complete and is qualified in its entirety by reference to the text of the Collaboration Agreement, a copy of which Sarepta intends to file as an exhibit to its Annual Report on Form 10-Kfor the year ended December 31, 2024.