Management Change/Compensation Form 8 K

(e)

Agreements with Former Chief Financial Officer and Treasurer

On October 31, 2024 (the "Separation Date"), Kimi Iguchi and Sage Therapeutics, Inc. (the "Company") entered into a separation agreement (the "Iguchi Separation Agreement") providing for the resignation of Ms. Iguchi from her positions as the Chief Financial Officer and Treasurer of the Company and from any and all other positions she holds as an officer or employee of the Company or an officer, employee or director of any of its subsidiaries. As previously announced, Ms. Iguchi's departure from the Company was part of the October 2024 reorganization of the Company's business operations and reduction in the Company's workforce (the "Reorganization"). The Iguchi Separation Agreement also includes a release of claims by Ms. Iguchi and non-solicitation,non-disclosureand non-disparagementobligations following the Separation Date.

Subject to the effectiveness of the release and compliance with such obligations, following the Separation Date, Ms. Iguchi is entitled in accordance with the Iguchi Separation Agreement to (i) the continuation of her base salary for twelve months following the Separation Date (the "Salary Continuation Period"), (ii) the payment of monthly premiums for healthcare coverage under COBRA to the same extent as if she had remained employed by the Company until the earlier of the end of the Salary Continuation Period and the date Ms. Iguchi becomes ineligible for the continuation of such coverage, and (iii) a bonus, equal to 50% of her bonus target for 2024, prorated for the time period between January 1, 2024 and the Separation Date.

On the Separation Date, the Company and Ms. Iguchi also entered into a Consulting Agreement (the "Iguchi Consulting Agreement") pursuant to which Ms. Iguchi has agreed to provide the Company consulting services until March 31, 2025 (the "Consulting Period"), which period may be extended by mutual agreement between Ms. Iguchi and the Company. In consideration for her services during the Consulting Period, the Company has agreed to pay Ms. Iguchi an hourly rate for her services, subject to a specified aggregate cap. The Iguchi Consulting Agreement is terminable prior to the end of the Consulting Period by either party upon ten days' prior written notice or upon a breach by the other party.

The Board of Directors of the Company (the "Board") also approved an amendment to Ms. Iguchi's outstanding option awards, restricted stock units and performance restricted stock unit awards to (a) provide that such options, restricted stock units, and performance restricted stock units shall continue to vest in accordance with their original terms for so long as Ms. Iguchi continues providing services to the Company as a consultant and (b) extend the period during which Ms. Iguchi may exercise any vested options to the later of (i) three months following the end of the Consulting Period and (ii) October 31, 2025, provided that no option may be exercised after its original expiration date.

The foregoing descriptions of the Iguchi Separation Agreement and Iguchi Consulting Agreement are qualified in their entirety by the full text of the Iguchi Separation Agreement and the Iguchi Consulting Agreement, respectively, copies of which are anticipated to be filed as exhibits to the Company's Annual Report on Form 10-Kfor the fiscal year ending December 31, 2024.

Separation Agreement with Former General Counsel and Secretary

On the Separation Date, Anne Marie Cook and the Company entered into a separation agreement (the "Cook Separation Agreement") providing for the resignation of Ms. Cook from her positions as Senior Vice President, General Counsel and Secretary of the Company and from any and all other positions she holds as an officer or employee of the Company or an officer, employee or director of any of its subsidiaries. As previously announced, Ms. Cook's departure from the Company was also part of the Reorganization. The Cook Separation Agreement also includes a release of claims by Ms. Cook and non-solicitation,non-disclosureand non-disparagementobligations following the Separation Date.

Subject to the effectiveness of the release and compliance with such obligations, following the Separation Date, Ms. Cook is entitled in accordance with the Cook Separation Agreement to (i) the continuation of her base salary during the Salary Continuation Period, (ii) the payment of monthly premiums for healthcare coverage under COBRA to the same extent as if she had remained employed by the Company until the earlier of the end of the Salary Continuation Period and the date Ms. Cook becomes ineligible for the continuation of such coverage, and (iii) a bonus, equal to 50% of her bonus target for 2024, prorated for the time period between January 1, 2024 and the Separation Date. The Board also approved an amendment to Ms. Cook's outstanding option awards to extend the period during which Ms. Cook may exercise any vested options from three months following the Separation Date to October 31, 2025, provided that no option may be exercised after its original expiration date.

The foregoing description of the Cook Separation Agreement is qualified in its entirety by the full text of the Cook Separation Agreement, a copy of which is anticipated to be filed as an exhibit to the Company's Annual Report on Form 10-Kfor the fiscal year ending December 31, 2024.