Material Agreement Form 8 K

On July 1, 2024, CARGO Therapeutics, Inc. (the "Company") entered into Sublease Agreement (the "Sublease") with Vaxcyte, Inc. ("Vaxcyte"), for a portion of the Company's headquarters located at 835 Industrial Road, San Carlos, California 94070 (the "Building"). The Company believes entering into the Sublease will optimize the utility of the office space during the term of the Sublease (described below). The Sublease commencement date was July 3, 2024.

The portion of the premises subject to the Sublease is approximately 38,200 rentable square feet. Pursuant to the Sublease, Vaxcyte will also have access to additional square feet of common amenities in the Building ("Shared Amenities Space"), at no additional cost to Vaxcyte.

The Sublease term will end on the day that is the last day of the 24^th month from the Commencement Date, with Vaxcyte having the right to extend the term of the Sublease for one additional 12-monthperiod unless the Company intends to reoccupy the space, unless sooner terminated or cancelled in accordance with the terms and conditions of the Sublease. Vaxcyte will be obligated to pay rent of approximately $214,000 per month (the "Base Rent"), with such Base Rent being abated for the first two (2) months following the commencement of the Sublease. Vaxcyte will be required to pay approximately 38% of the operating expenses as specified in the Sublease.

The Sublease is included as Exhibit 10.1 to this current report on Form 8-Kand is incorporated herein by reference. The foregoing description of the Sublease does not purport to be complete and is qualified in its entirety by reference to the Sublease.