Skyrizi Dosages for Adults: Your GoodRx Guide

GoodRx Health

Skyrizi (risankizumab-rzaa) is a biologic medication that treats several autoimmune disorders. It blocks a specific protein called an interleukin from causing inflammation in your body. This helps lessen the symptoms of your health condition.

Skyrizi is an injectable medication that you'll either receive at a medical office or give yourself at home. And you don't use it every day - just once every 8 to 12 weeks after your first few doses. That's 4 to 6 times a year.

Below, we'll look at the various Skyrizi dosages and dosage forms. Keep in mind that these are general guidelines. Your prescriber may tell you to use Skyrizi differently than what's listed below. Be sure to follow their instructions.

What's the typical Skyrizi dosage for adults?

Your Skyrizi dosage depends on what you're taking it for. Skyrizi is approved to treat plaque psoriasis, psoriatic arthritis, and inflammatory bowel disease. Inflammatory bowel disease includes Crohn's disease and ulcerative colitis.

No matter what condition you're treating, Skyrizi requires more frequent dosing when you first start using it. These are called loading doses, because they help "load" the medication into your body to increase Skyrizi levels quickly. This helps it start working faster.

After your loading doses, you'll switch to a maintenance dose. Maintenance doses are given further apart than loading doses and may also be a lower dose.

Below are the recommended Skyrizi dosages for adults. At this time, Skyrizi is not approved for children.

Plaque psoriasis

For plaque psoriasis, the loading dose of Skyrizi is 150 mg injected under the skin, followed by a second 150 mg dose 4 weeks later. After that, the maintenance Skyrizi dosage is 150 mg injected under the skin every 12 weeks.

Psoriatic arthritis

The Skyrizi dosages for plaque psoriasis and psoriatic arthritis are the same. For psoriatic arthritis, the recommended Skyrizi loading dosage is a two-dose series of 150 mg injections given 4 weeks apart. After that, you'll continue with a maintenance Skyrizi dosage of 150 mg injected under the skin every 12 weeks.

Crohn's disease

For Crohn's disease, the recommended Skyrizi dosage starts with 3 loading doses of 600 mg, each given 4 weeks apart. The loading doses of Skyrizi for Crohn's disease are not injections. Instead, they're infusions that are given into a vein (IV) over at least 1 hour. So you'll need to receive your loading doses in a medical office or infusion center.

The maintenance dose of Skyrizi starts 4 weeks after the last infusion. The recommended dosage is 180 mg or 360 mg injected under the skin every 8 weeks.

Ulcerative colitis

For ulcerative colitis, the recommended Skyrizi dosage starts with 3 IV infusions of 1,200 mg, each given 4 weeks apart. You'll receive your loading doses in a medical office or infusion center.

The maintenance dose of Skyrizi starts 4 weeks after the last infusion. The recommended dosage is 180 mg or 360 mg injected under the skin every 8 weeks. In most cases, you can give your maintenance doses to yourself at home.

What are the different dosage forms of Skyrizi?

The different forms and doses of Skyrizi are shown in the chart below.

The vial of Skyrizi is used by a healthcare professional for IV infusion. You shouldn't use this dosage form on your own.

The Skyrizi injection pen, syringes, and on-body injectors can be used at home. You can inject Skyrizi into your thigh or stomach. You can also receive an injection on your upper outer arm if someone else is injecting it for you.

These dosage forms are all prefilled and can't be used more than once. You should dispose of each Skyrizi dose in a sharps container once you've used it.

Your prescriber will show you how to use your dosage form before you use it on your own. But you should reach out to your healthcare team at any time if you have questions about how to inject Skyrizi.

You should store Skyrizi in the refrigerator. But it will help make injections less painful if you allow it to reach room temperature before you inject it.

What happens if you miss a dose of Skyrizi?

If you miss a dose of Skyrizi, inject it as soon as you remember. You can resume your regular dosing schedule after that. It's also fine to reach out to your healthcare team if you miss your dose and have questions about what to do. They can help you get back on track.

An advantage of Skyrizi is that after your loading doses, you only need to inject it 4 or 6 times a year. While fewer injections are a huge benefit, it can be easier to forget your dose when they're so far apart. To help prevent missed doses, try using a medication reminder app on your smartphone. You can also mark your yearly calendar and hang it somewhere in your home that you see often (such as on the fridge).

What should you do if you take too much Skyrizi?

Since Skyrizi only comes in single doses, it's difficult to inject too much. If you aren't sure if you've injected Skyrizi or not, count the doses you have left in the fridge. That may help you figure out if you have an extra or not. If you still aren't sure, contact your prescriber for next steps.

If you've already injected more Skyrizi than prescribed, contact your prescriber or call Poison Control at 1-800-222-1222.

How to save on Skyrizi

There are ways to save on Skyrizi, which is only available as a brand-name medication. GoodRx can help you navigate between patient assistance programs and copay savings cards to save money on your prescription.

• Save with a copay savings card. If you have commercial insurance, you may be eligible to pay as little as $5 per dose of Skyrizi using a savings card from the manufacturer.

• Save with patient assistance programs. If you're uninsured or underinsured and meet certain income requirements, you may be eligible for Skyrizi's patient assistance program, which offers the medication at no cost.

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