Samsara BioCapital LP

10/11/2024 | Press release | Distributed by Public on 10/11/2024 14:16

Beneficial Ownership Report - Form SC 13G

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No. )*

OnKure Therapeutics, Inc.

(Name of Issuer)

Class A Common Stock, par value $0.0001 per share

(Title of Class of Securities)

68277Q105

(CUSIP Number)

October 4, 2024

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

¨ Rule 13d-1(b)
x Rule 13d-1(c)
¨ Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 68277Q105
1.

Names of Reporting Persons

Samsara BioCapital, L.P.

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) ¨(b) x (1)

3. SEC Use Only
4.

Citizenship or Place of Organization

Delaware

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person With

5.

Sole Voting Power

0

6.

Shared Voting Power

824,155 (2)

7.

Sole Dispositive Power

0

8.

Shared Dispositive Power

824,155 (2)

9.

Aggregate Amount Beneficially Owned by Each Reporting Person

824,155 (2)

10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨
11.

Percent of Class Represented by Amount in Row (9)

6.5% (3)

12.

Type of Reporting Person (See Instructions)

PN

(1) This Schedule 13G is filed by Samsara BioCapital, L.P. ("Samsara LP"), Samsara BioCapital GP, LLC ("Samsara GP") and Dr. Srinivas Akkaraju ("Dr. Akkaraju") (and together with Samsara LP, Samsara GP, the "Reporting Persons"). The Reporting Persons expressly disclaim status as a "group" for purposes of this Schedule 13G.
(2) These shares are held by Samsara LP. Samsara GP is the sole general partner of Samsara LP and may be deemed to have voting and investment power over the securities held by Samsara LP. Dr. Akkaraju is the managing member of Samsara GP and may be deemed to have voting and dispositive power over the shares held by Samsara LP.
(3) This percentage is calculated based on 12,652,811 shares of Class A Common Stock outstanding as of October 4, 2024, as reported in the Issuer's Current Report on Form 8-K filed with the Securities and Exchange Commission (the "SEC") on October 8, 2024.

2

CUSIP No. 68277Q105
1.

Names of Reporting Persons

Samsara BioCapital GP, LLC

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) ¨(b) x (1)

3. SEC Use Only
4.

Citizenship or Place of Organization

Delaware

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person With

5.

Sole Voting Power

0

6.

Shared Voting Power

824,155 (2)

7.

Sole Dispositive Power

0

8.

Shared Dispositive Power

824,155 (2)

9.

Aggregate Amount Beneficially Owned by Each Reporting Person

824,155 (2)

10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨
11.

Percent of Class Represented by Amount in Row (9)

6.5% (3)

12.

Type of Reporting Person (See Instructions)

OO

(1) This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a "group" for purposes of this Schedule 13G.
(2) These shares are held by Samsara LP. Samsara GP is the sole general partner of Samsara LP and may be deemed to have voting and investment power over the securities held by Samsara LP. Dr. Akkaraju is the managing member of Samsara GP and may be deemed to have voting and dispositive power over the shares held by Samsara LP.
(3) This percentage is calculated based on 12,652,811 shares of Class A Common Stock outstanding as of October 4, 2024, as reported in the Issuer's Current Report on Form 8-K filed with the SEC on October 8, 2024.

3

CUSIP No. 68277Q105
1.

Names of Reporting Persons

Srinivas Akkaraju

2.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) ¨(b) x (1)

3. SEC Use Only
4.

Citizenship or Place of Organization

United States

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person With

5.

Sole Voting Power

0

6.

Shared Voting Power

824,155 (2)

7.

Sole Dispositive Power

0

8.

Shared Dispositive Power

824,155 (2)

9.

Aggregate Amount Beneficially Owned by Each Reporting Person

824,155 (2)

10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨
11.

Percent of Class Represented by Amount in Row (9)

6.5% (3)

12.

Type of Reporting Person (See Instructions)

IN

(1) This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a "group" for purposes of this Schedule 13G.
(2) These shares are held by Samsara LP. Samsara GP is the sole general partner of Samsara LP and may be deemed to have voting and investment power over the securities held by Samsara LP. Dr. Akkaraju is the managing member of Samsara GP and may be deemed to have voting and dispositive power over the shares held by Samsara LP.
(3) This percentage is calculated based on 12,652,811 shares of Class A Common Stock outstanding as of October 4, 2024, as reported in the Issuer's Current Report on Form 8-K filed with the SEC on October 8, 2024.

4

Item 1.
(a) Name of Issuer
OnKure Therapeutics, Inc.
(b)

Address of Issuer's Principal Executive Offices

6707 Winchester Circle, Suite 400, Boulder, CO 80301

Item 2.
(a)

Name of Person Filing

Samsara BioCapital, L.P. ("Samsara LP")

Samsara BioCapital GP, LLC ("Samsara GP")

Srinivas Akkaraju ("Dr. Akkaraju")

(b)

Address of Principal Business Office or, if none, Residence

c/o Samsara BioCapital, LLC

628 Middlefield Road

Palo Alto, CA 94301

(c) Citizenship
Entities: Samsara LP - Delaware
Samsara GP - Delaware
Individuals: Dr. Akkaraju - United States
(d)

Title of Class of Securities

Class A Common Stock, par value $0.0001 per share ("Class A Common Stock")
(e) CUSIP Number

68277Q105

Item 3. If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
Not applicable
Item 4. Ownership

The following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1 is provided as of October 11, 2024:

Reporting
Persons

Shares Held
Directly

Sole
Voting
Power

Shared
Voting
Power (1)

Sole
Dispositive
Power

Shared
Dispositive
Power (1)

Beneficial
Ownership
(1)

Percentage
of Class (2)

Samsara LP 824,155 0 824,155 0 824,155 824,155 6.5%
Samsara GP 0 0 824,155 0 824,155 824,155 6.5%
Dr. Akkaraju 0 0 824,155 0 824,155 824,155 6.5%

(1)     These shares are held by Samsara LP. Samsara GP is the sole general partner of Samsara LP and may be deemed to have voting and investment power over the securities held by Samsara LP. Dr. Akkaraju is the managing member of Samsara GP and may be deemed to have voting and dispositive power over the shares held by Samsara LP.

(2)     This percentage is calculated based on 12,652,811 shares of Class A Common Stock outstanding as of October 4, 2024, as reported in the Issuer's Current Report on Form 8-K filed with the SEC on October 8, 2024.

5

Item 5. Ownership of Five Percent or Less of a Class
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ¨
Item 6. Ownership of More than Five Percent on Behalf of Another Person
Not applicable
Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person
Not applicable
Item 8. Identification and Classification of Members of the Group
Not applicable
Item 9. Notice of Dissolution of Group
Not applicable
Item 10. Certification
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purpose or effect.

6

Signature

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: October 11, 2024

Samsara BioCapital, L.P.
By: Samsara BioCapital GP, LLC
its General Partner
By: /s/ Srinivas Akkaraju
Name: Srinivas Akkaraju
Title: Managing Member
Samsara BioCapital GP, LLC
By: /s/ Srinivas Akkaraju
Name: Srinivas Akkaraju
Title: Managing Member
/s/ Srinivas Akkaraju
Srinivas Akkaraju
ATTENTION
Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).

7

Exhibit(s):

A Joint Filing Agreement

8

EXHIBIT A

JOINT FILING AGREEMENT

We, the undersigned, hereby express our agreement that the attached Schedule 13G (or any amendments thereto) relating to the Class A Common Stock of OnKure Therapeutics, Inc. is filed on behalf of each of us.

Dated: October 11, 2024

Samsara BioCapital, L.P.
By: Samsara BioCapital GP, LLC
its General Partner
By: /s/ Srinivas Akkaraju
Name: Srinivas Akkaraju
Title: Managing Member
Samsara BioCapital GP, LLC
By: /s/ Srinivas Akkaraju
Name: Srinivas Akkaraju
Title: Managing Member
/s/ Srinivas Akkaraju
Srinivas Akkaraju