Management Change/Compensation Form 8 K

On November 18, 2024, Acadia Pharmaceuticals Inc. (the "Company") agreed with Brendan Teehan, Executive Vice President, Chief Operating Officer and Head of Commercial that he would be involuntarily terminated without Cause (as such term is defined in the Company's Management Severance Benefit Plan (the "Severance Plan")) from his position, effective immediately. Mr. Teehan will remain employed by the Company as a non-executiveemployee until December 31, 2024 to assist with the orderly transition of duties and responsibilities to a successor. Until a successor is appointed, Mr. Teehan's responsibilities will be assumed by Catherine Owen Adams, the Company's Chief Executive Officer, who has more than 30 years of commercial experience in the pharmaceutical industry.