Presentation to Annual General Meeting Form 6 K

13 Brain Iron Brain Volume Iron content was stable in the s. nigra, putamen and globus pallidus over 12 mo in clinical responders Brain volume stable between 6 and 12 mo in clinical responders MRI data at 6 months (n=10) and 12 months (n=3) NfL (neurofilament light chain) data at 6 months. ATH434 - 202 Interim Biomarker Data Support Clinical Observations Mean levels of NfL, a marker of neuronal injury only 2.7% in ATH434 - patients compared to 17.9% in untreated patients (bioMUSE) Neuronal Injury Marker ATH434-202 bioMuse -40 -20 0 20 40 60 80 % c h a n g e i n C S F N f L a t 6 m o n Participants who stabilized or improved had less advanced disease