Amendment to Quarterly Report Form 10 Q/A

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q/A

(Amendment No. 1)

(Mark One)

☒

Quarterly Report UNDER Section 13 or 15(d) of the Securities Exchange Act of 1934

For the quarterly period ended March 31, 2024

OR

☐

Transition Report UNDER Section 13 or 15(d) of the Securities Exchange Act of 1934

For the transition period from ______________ to ______________

Commission file number 001-41488

SHUTTLE PHARMACEUTICALS HOLDINGS, INC.

(Exact name of registrant as specified in its charter)

Delaware		82-5089826
(State or other jurisdiction of		(I.R.S. Employer
incorporation or organization)		Identification Number)

401 Professional Drive, Suite 260

Gaithersburg, MD20879

(Address of principal executive offices) (Zip Code)

(240)403-4212

(Registrant's telephone number, including area code)

N/A

(Former name, former address and former fiscal year, if changed since last report)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class		Trading Symbol(s)		Name of each exchange on which registered
Common Stock		SHPH		The NasdaqStock Market LLC

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

	Large accelerated filer	☐	Accelerated filer	☐
	Non-accelerated filer	☒	Smaller reporting company	☒
			Emerging growth company	☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐Indicate by check mark if the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No☒

The number of shares outstanding of the registrant's common stock on September 3, 2024 was 2,226,951.

EXPLANATORY NOTE

This Amendment No. 1 to Form 10-Q/A (the "Amendment No.1") amends the Quarterly Report on Form 10-Q of Shuttle Pharmaceuticals Holdings, Inc. (the "Company") for the fiscal quarter ended March 31, 2024, as filed with the Securities and Exchange Commission, or the SEC, on May 13, 2024 (the "Original Filing"). As previously reported, following the entry of a cease-and-desist order entered on May 3, 2024 by the SEC against our former auditor, B.F. Borgers CPA PC ("BF Borgers"), we commenced the re-audit (the "Re-audit") of our financial statements for the year ended December 31, 2022, which had been audited by BF Borgers. Since that time and as a result of the Re-audit, as of July 10, 2024, the Company and the audit committee of our board of directors, in consultation with our current auditor, Forvis Mazars, LLP, concluded that our audited financial statements for the year ended December 31, 2022 (the "2022 Financial Statements"), our audited financial statements for the year ended December 31, 2023 and the quarterly periods included in the Company's Form 10-K, and the Original Filing require restatement and are not reliable.

Shuttle Pharmaceuticals Holdings, Inc.

TABLE OF CONTENTS

		Page No.
	PART I. Financial Information
Item 1.	Unaudited Condensed Consolidated Financial Statements	1
	Unaudited Condensed Consolidated Balance Sheets as of March 31, 2024 and December 31, 2023	1
	Unaudited Condensed Consolidated Statements of Operations for the three months ended March 31, 2024 and 2023	2
	Unaudited Condensed Consolidated Statements of Changes in Stockholders' Equity for the three months ended March 31, 2024 and 2023	3
	Unaudited Condensed Consolidated Statements of Cash Flows for the three months ended March 31, 2024 and 2023	4
	Notes to Unaudited Condensed Consolidated Financial Statements	5
Item 2.	Management's Discussion and Analysis of Financial Condition and Results of Operations	19
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	24
Item 4.	Controls and Procedures	25
	PART II. Other Information
Item 1.	Legal Proceedings	26
Item 1A.	Risk Factors	26
Item 2.	Unregistered Sale of Equity Securities and Use of Proceeds	26
Item 3.	Defaults Upon Senior Securities	26
Item 4.	Mine Safety Disclosures	26
Item 5.	Other Information	26
Item 6.	Exhibits	26
	Signatures	27

PART I. Financial Information

Item 1. Unaudited Condensed Consolidated Financial Statements

Shuttle Pharmaceuticals Holdings, Inc.

Condensed Consolidated Balance Sheets

(Unaudited)

		March 31,			December 31,
		2024 (as restated)			2023 (as restated)
Assets
Current assets
Cash and cash equivalents		$	1,398,628			$	2,576,416
Prepaid expenses			129,642				114,473
Marketable securities			2,789,251				2,887,215
Accrued interest income			11,964				14,901
Other current assets			81,534				-
Total current assets			4,411,019				5,593,005
Property and equipment, net			22,915				24,827
Operating lease right-of-use asset			319,987				333,904
Total Assets		$	4,753,921			$	5,951,736
Liabilities and Stockholders' Equity
Current Liabilities
Accounts payable and accrued expenses		$	347,556			$	282,860
Accounts payable and accrued expenses related party			-				446
Accrued interest payable			143,676				110,453
Convertible notes payable, net			941,398				595,999
Derivative liability			2,035				-
Operating lease liability			54,552				52,479
Total Current Liabilities			1,489,217				1,042,237
Convertible notes payable non-current, net			-				135,089
Derivative liabilities non-current			214,615				414,512
Operating lease liability non-current			288,602				304,127
Total Liabilities			1,992,434				1,895,965
Stockholders' Equity
Series A Convertible Preferred Stock, $0.00001par value; $1,000per share liquidation value; 20,000,000shares authorized; noshares outstanding			-				-
Common stock, $0.00001par value; 100,000,000shares authorized; 2,102,511and 2,008,689shares issued and outstanding, respectively			21				20
Additional paid in capital, as restated			29,925,801				29,489,055
Accumulated deficit, as restated			(27,164,335	)			(25,433,304	)
Total Stockholders' Equity			2,761,487				4,055,771
Total Liabilities and Stockholders' Equity		$	4,753,921			$	5,951,736

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Shuttle Pharmaceuticals Holdings, Inc.

Condensed Consolidated Statements of Operations

(Unaudited)

		Three Months Ended
		March 31,
		2024			2023
Revenue		$	-			$	-
Operating expenses
Research and development			586,104				921,801
General and administrative			324,609				255,355
Legal and professional			474,134				367,624
Total operating expenses			1,384,847				1,544,780
Loss from operations			(1,384,847	)			(1,544,780	)
Other income (expense)
Interest expense - related parties			-				(4,237	)
Interest expense			(497,515	)			(599,331	)
Interest income			21,453				16,688
Finance fee			-				(104,245	)
Change in fair value of derivative liabilities			197,862				1,241,000
Gain on sale of marketable securities			4,037				-
Change in fair value of marketable securities			(706	)			38,062
Loss on settlement of convertible debt			(71,315	)			(18,254	)
Total other income (expense)			(346,184	)			569,683
Net loss attributable to common stockholders		$	(1,731,031	)		$	(975,097	)
Weighted average common shares outstanding - basic and diluted			2,075,745				1,704,517
Net loss per shares - basic and diluted		$	(0.83	)		$	(0.57	)

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Shuttle Pharmaceuticals Holdings, Inc.

Condensed Consolidated Statements of Changes in Stockholders' Equity (Deficit)

(Unaudited)

For the Three Months Ended March 31, 2024

								Additional						Total
		Common Stock			Paid in			Accumulated			Stockholders'
		Shares			Amount			Capital			Deficit			Equity
Balance at December 31, 2023 (as restated)			2,008,689			$	20			$	29,489,055			$	(25,433,304	)		$	4,055,771
Common stock issued for conversion of accrued interest and principal			78,197				1				325,297				-			$	325,298
Common stock issued for restricted stock units			15,625				-				-				-			$	-
Stock-based compensation			-				-				111,449				-			$	111,449
Net loss			-				-				-				(1,731,031	)		$	(1,731,031	)
Balance at March 31, 2024 (as restated)			2,102,511			$	21			$	29,925,801			$	(27,164,335	)		$	2,761,487

For the Three Months Ended March 31, 2023

								Additional						Total
		Common Stock			Paid in			Accumulated			Stockholders'
		Shares			Amount			Capital			Deficit			Equity (Deficit)
Balance - December 31, 2022 (as restated)			1,700,414			$	17			$	26,518,433			$	(18,840,581	)		$	7,677,869
Warrants issued for financing costs			-				-				90,816				-				90,816
Common stock issued for conversion of accrued interest and principal			6,375				-				104,547				-				104,547
Stock-based compensation			-				-				8,333				-				8,333
Net loss			-				-				-				(975,097	)			(975,097	)
Balance - March 31, 2023 (as restated)			1,706,789			$	17			$	26,722,129			$	(19,815,678	)		$	6,906,468

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Shuttle Pharmaceuticals Holdings, Inc.

Condensed Consolidated Statements of Cash Flows

(Unaudited)

		Three Months Ended
		March 31,
		2024			2023
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss		$	(1,731,031	)		$	(975,097	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation			1,912				1,488
Change in fair value of derivative liability			(197,862	)			(1,241,000	)
Amortization of debt discount and finance fees			445,509				567,297
Gain on marketable securities			(4,037	)			-
Change in fair value of marketable securities			706				(38,062	)
Accrued interest settled with common stock			18,783				20,142
Loss on settlement of convertible debt			71,315				18,254
Stock-based compensation			111,449				8,333
Changes in operating assets and liabilities:
Accrued interest income			2,937				(7,023	)
Prepaid expenses			(15,169	)			(42,687	)
Accounts payable and accrued expenses			23,162				330,729
Accounts payable and accrued expenses - related parties			(446	)			(12,500	)
Accrued interest payable			33,223				116,051
Accrued interest payable - related parties			-				(74,807	)
Other assets			-				(7,206	)
Change in operating lease asset and liabilities			466				(1,894	)
Net cash used in operating activities			(1,239,083	)			(1,337,982	)
CASH FLOWS FROM INVESTING ACTIVITIES:
Investment in marketable securities			(18,705	)			(2,953,709	)
Proceeds from disposition of marketable securities			120,000				-
Net cash used in investing activities			101,295				(2,953,709	)
CASH FLOWS FROM FINANCING ACTIVITIES:
Repayment of note payable-related party			-				(546,244	)
Proceeds from convertible notes payable and warrants			-				3,935,000
Payment for finance costs related to convertible note payable			-				(345,000	)
Payment for finance costs			(40,000	)			-
Net cash provided by financing activities			(40,000	)			3,043,756
Net change in cash and cash equivalents			(1,177,788	)			(1,247,935	)
Cash and cash equivalents, beginning of period			2,576,416				8,417,203
Cash and cash equivalents, end of period		$	1,398,628			$	7,169,268
Cash paid for:
Interest		$	-			$	79,044
Income taxes		$	-			$	-
Supplemental non-cash financing activities:
Common stock issued for settlement of debt		$	325,298			$	104,547
Finance costs accrued in accounts payable		$	41,534			$	-
Warrants issued for financing fees, net of issuance fees of $0and $8,727, respectively		$	-			$	90,816

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Note 1 - Organization and Liquidity

Organization and Line of Business

Shuttle Pharmaceuticals Holdings, Inc. ("we", "us", "our", the "Company") was originally formed as Shuttle Pharmaceuticals, LLC in the State of Maryland on December 18, 2012. On August 12, 2016, the Company filed articles of conversion with the State of Maryland to convert from an LLC to a C corporation, at which time the Company changed its name to Shuttle Pharmaceuticals, Inc. ("Shuttle"). In connection with the conversion the Company issued 5,625,000shares of common stock in exchange for 100% of the outstanding membership interests in Shuttle prior to conversion. On June 4, 2018, Shuttle completed a reverse merger with Shuttle Pharmaceuticals Holdings, Inc. (then known as Shuttle Pharma Acquisition Corp, Inc.), a Delaware corporation, pursuant to which Shuttle, our operating entity, became a wholly owned subsidiary of the Company. All share numbers referenced herein reflect a 1-for-8 reverse splitof our common stock on a post-split basis, which was effective as of August 13, 2024 (see Note 2).

The Company's primary purpose is to develop and commercialize unique drugs for the sensitization of cancers and protection of normal tissues, with the goal of improving outcomes for cancer patients receiving radiation therapy. Shuttle has deployed its proprietary technology to develop novel cancer immunotherapies, producing a pipeline of selective HDAC inhibitors for cancer and immunotherapy applications. The Company's HDAC platform is designed to target candidate molecules with potential roles in therapeutics beyond cancer, including autoimmune, inflammatory, metabolic, neurological and infectious diseases. The Company's Ropidoxuridine product, which is used with radiation therapy to sensitize cancer cells, was initially funded by a Small Business Innovation Research ("SBIR") contract provided by the National Cancer Institute ("NCI"), a unit of the National Institutes of Health ("NIH"). Ropidoxuridine has been further developed though the Company's collaborations with scientists at the University of Virginia for use in combination with proton therapy to improve patient survival. Historically, and prior to the Company's initial public offering in September 2022, the Company has obtained funding to develop products through NIH grants, including a product to predict late effects of radiation with metabolite biomarkers and develop prostate cancer cell lines in health disparities research.

The production and marketing of the Company's products and its ongoing research and development activities will be and are subject to extensive regulation by numerous governmental authorities in the United States. Prior to marketing in the United States, any products or combination of products developed by the Company must undergo rigorous preclinical (animal) and clinical (human) testing and an extensive regulatory approval process implemented by the Food and Drug Administration ("FDA") under the Food, Drug and Cosmetic Act. There can be no assurance that the Company will not encounter problems in its clinical trials that will cause the Company or the FDA to delay or suspend the clinical trials.

The Company's success will depend in part on its ability to obtain patents and product license rights, maintain trade secrets, and operate without infringing on the proprietary rights of others, both in the United States and in other countries. There can be no assurance that patents issued to or licensed by the Company will not be challenged, invalidated or circumvented, or that the rights granted thereunder will provide proprietary protection or competitive advantages to the Company now or in the future.

Liquidity and Going Concern

Our condensed consolidated financial statements are prepared on a going concern basis, which contemplates the realization of assets and the satisfaction of liabilities and commitments in the normal course of business. The Company has incurred losses since inception and has a net loss of approximately $1.7million and norevenues for the three months ended March 31, 2024 and has working capital of approximately $2.9million as of March 31, 2024. In addition, the convertible note payable outstanding at March 31, 2024 includes covenants and certain cash payment requirements. On July 12, 2024, the Company informed the investor of its convertible note that the Company's expected restatement of its financial statements for the years ended December 31, 2022 and 2023 constituted an event of default under the terms of the convertible note. On August 6, 2024, the Company paid $0.6million to the investor of the convertible note and received a waiver from the investor related to the default. The funds paid are restricted and will be held as collateral to the balance owed under the convertible note (see Note 9). These conditions, and the Company's ability to comply with such conditions, raise substantial doubt about the Company's ability to continue as a going concern within one year after the date that the condensed consolidated financial statements are issued.

In January 2023, the Company entered into a securities purchase agreement with an institutional investor through which the Company sold a convertible note with a principal value of $4.3million, along with a four-year warrant to purchase 127,260shares of common stock, exercisable at $18.80per share, providing the Company with approximately $3.6million in net proceeds. To date, the warrant has not yet been exercised. However, the Company's existing cash resources, marketable securities and the cash received from the equity offering and convertible note are not expected to provide sufficient funds to carry out the Company's operations and clinical trials through the next twelve months.

The IPO and subsequent capital raise have supported operations leading up to the manufacture of drug product and FDA approval of the IND for the Phase II clinical trial of Ropidoxuridine and radiation therapy in glioblastoma. The FDA recommended and the Company agreed to an expansion of the clinical trial, necessitating additional capital to complete the trial as well as fund ongoing operations. As a result, we are in the process of filing a registration statement on Form S-1 to raise additional capital. We presently intend to commence the capital raise shortly after we complete the Re-audit noted below in Note 2, Restatement of Previously Issued Financial Statements. The Company may also pursue additional bridge financing pending the completion of the registration statement.

The accompanying condensed consolidated financial statements do not include any adjustments to reflect the future effects on the recoverability and classification of assets or the amounts and classification of liabilities if the Company is unable to continue as a going concern.

Reverse Stock Split

On August 13, 2024, in order to meet Nasdaq's minimum bid price requirement of $1.00per share (the "Minimum Bid Price Requirement"), the Company effectuated a 1-for-8 reverse stock splitof its issued and outstanding common stock, rounding up to account for any fractional shares (the "Reverse Stock Split"). The Reverse Stock Split had no effect on the Company's authorized shares of common stock or preferred stock. Following the reverse stock split on August 13, 2024, the Company had a total of 2,111,235shares issued and outstanding (or 2,102,511on a post-split basis as of March 31, 2024). The Reverse Stock Split also resulted in an adjustment to the consolidated balance sheet for the period ended March 31, 2024 and the year ended December 31, 2023 within additional paid in capital of $147and $141, respectively, and an offsetting adjustment to the carrying value of common stock. All share, option, warrant and per share amounts (except our authorized outstanding) have been retroactively restated in these financial statements and related disclosures. The effect of the Reverse Stock Split has been included in Note 2 in the "As Reported" amounts for additional paid in capital.

Note 2 - Restatement of Previously Issued Financial Statements

As previously disclosed in the Company's Quarterly Report on Form 10-Q for the period ended March 31, 2024, filed with the Securities and Exchange Commission ("SEC") on May 13, 2024, following the entry of a cease-and-desist order by the SEC against our former auditor, B.F. Borgers CPA PC ("BF Borgers"), we commenced the re-audit (the "Re-audit") of our financial statements for the year ended December 31, 2022, which had been audited by BF Borgers. Since that time and as a result of the Re-audit, and as initially disclosed on Form 8-K dated July 10, 2024, the Company and the Audit Committee have concluded and informed our current auditor, Forvis Mazars, LLP, that our audited financial statements for the year ended December 31, 2022 (the "2022 Financial Statements"), our audited financial statements for the year ended December 31, 2023 (the "2023 Financial Statements"), and the quarterly periods included in the Company's Annual Report for the year ended December 31, 2023, and the quarterly report for the period ended March 31, 2024 require restatement and are not reliable.

The accounting errors impacting our 2022 Financial Statements include:

Stock Compensation

	●	Application of the incorrect grant date fair values in determining the value of certain equity awards granted during the years ended December 31, 2019 and 2020;
	●	Miscalculation of the pattern of recognition of stock-based compensation over the requisite service periods for certain equity awards granted during the years ended December 31, 2019 and 2020;

Series A Convertible Preferred Stock

	●	Utilization of incorrect inputs to the fair value estimates for the warrant obligation related to the Series A Convertible Preferred Stock; incorrectly recording the reclassification of the warrant obligation upon issuance as a gain and not as a reclassification to stockholders' equity;
	●	Recording of accrued dividends on the Series A Convertible Preferred Stock as a liability prior to the dividends being declared;
	●	Failure to recognize the accounting impact for the amendment to the terms of the Series A Convertible Preferred Stock in April 2022, which the Company subsequently concluded should have been recognized as an extinguishment;
	●	Failure to recognize deemed contribution related to the settlement of the Series A Convertible Preferred Stock and accrued dividends;

Notes Payable

	●	Misidentification of certain debt and equity issuance costs and incorrect association with certain of the Company's financings during the years ended December 31, 2022 and 2021;
	●	Application of the incorrect amortization period and pattern of recognition for debt discounts recorded in relation to the Company's debt financings during the years ended December 31, 2022 and 2021;
	●	Incorrect recognition of bifurcated derivative liabilities, as well as incorrect initial and subsequent fair value measurements, in relation to the December 2021 Notes, 2022 Convertible Notes and August 2022 Notes;
	●	Misclassification of certain warrants issued with debt transactions during the year ended December 31, 2022;
	●	Failure to recognize certain liability-classified warrants issued in exchange for services provided related to the Company's financing activities during the year ended December 31, 2022;
	●	Incorrect application of extinguishment or conversion models in accounting for certain debt instruments upon their settlement; and

Initial Public Offering

●

Incorrect identification of deferred issuance costs incurred in relation to the initial public offering; Incorrect identification and classification of issuance costs incurred in relation to the initial public offering.

The impact of the errors described above also impact the Company's Quarterly Report on Form 10-Q for the period ended March 31, 2024 and March 31, 2023 within Additional Paid In Capital and Accumulated Deficit, resulting in the presentation and filing of this Quarterly Report on Form 10-Q/A.

The Company's prior and updated accounting for the errors described above do not have any effect on the Company's previously reported cash or cash flows.

The following tables summarize the effect of the restatement on each financial statement line item as of the dates indicated:

Consolidated Balance Sheet as of March 31, 2024		As Reported			Adjustment			As Restated
Additional paid in capital			19,980,109				9,945,692				29,925,801
Accumulated deficit			(17,218,643	)			(9,945,692	)			(27,164,335	)

Consolidated Balance Sheet as of December 31, 2023		As Reported			Adjustment			As Restated
Additional paid in capital			19,543,363				9,945,692				29,489,055
Accumulated deficit			(15,487,612	)			(9,945,692	)			(25,433,304	)

Note 3 - Summary of Significant Accounting Policies

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America ("GAAP") for interim financial statements and with the instructions to Form 10-Q and Rule 8-03 of Regulation S-X of the United States Securities and Exchange Commission ("SEC"). Accordingly, they do not contain all information and notes required by accounting principles generally accepted in the United States of America for annual financial statements. A complete discussion of the Company's significant accounting policies is included in the Company's Annual Report on Form 10-K for the year ended December 31, 2023.

In the opinion of the Company's management, the accompanying unaudited condensed consolidated financial statements contain all of the adjustments necessary to present the financial position of the Company as of March 31, 2024 and the results of operations and cash flows for the periods presented. The accompanying condensed consolidated financial statements of the Company have not been audited by the Company's independent registered public accounting firm, except that the year-end condensed consolidated balance sheet was derived from audited financial statements. The results of operations for the three months ended March 31, 2024 are not necessarily indicative of the operating results for the full fiscal year or any future period. These unaudited condensed consolidated financial statements should be read in conjunction with the financial statements and related notes thereto for the year ended December 31, 2023 included in the Company's Annual Report on Form 10-K/A filed with the SEC on [August [*], 2024].

Basis of Consolidation

The unaudited condensed consolidated financial statements have been prepared on a consolidated basis with those of the Company's wholly-owned subsidiaries, Shuttle Pharmaceuticals, Inc. and Shuttle Diagnostics, Inc. All intercompany transactions and balances have been eliminated.

Use of Estimates

The preparation of condensed consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. The Company regularly evaluates estimates and assumptions. The Company bases its estimates and assumptions on current facts, historical experience, and various other factors that it believes to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities and the accrual of costs and expenses that are not readily apparent from other sources. The actual results experienced by the Company may differ materially and adversely from the Company's estimates. To the extent there are material differences between the estimates and the actual results, future results of operations will be affected. Significant estimates are contained in the accompanying condensed consolidated financial statements for the recognition of research and development expenses, valuation of warrants and valuation of bifurcated derivative liabilities and other financial instruments.

Cash and Cash Equivalents

Cash and cash equivalents include cash in bank accounts and money market funds with maturities of less than three months from inception, which are readily convertible to known amounts of cash and which, in the opinion of management, are subject to an insignificant risk of loss in value. As of March 31, 2024 and December 31, 2023, cash and cash equivalents consisted of the following:

		March 31,			December 31,
		2024			2023
Cash		$	364,069			$	1,550,098
Money market funds			1,034,559				1,026,318
	$	1,398,628			$	2,576,416

Periodically, the Company may carry cash balances at financial institutions in excess of the federally insured limit of $250,000per institution. The amount in excess of the FDIC insurance as of March 31, 2024 was approximately $1.1million. The Company has not experienced losses on these accounts and management believes, based upon the quality of the financial institutions, that the credit risk with regard to these deposits is not significant.

Marketable Securities

Our investments in debt securities are carried at fair value. Investments in debt securities that are not classified as held-to-maturity are carried at fair value and classified as either trading or available-for-sale. Realized and unrealized gains and losses on trading of debt securities are charged to income.

The marketable securities held by the Company, which are classified as trading marketable securities, consisted of an outstanding balance of $2,789,251and $2,887,215as of March 31, 2024 and December 31, 2023, respectively. During the three months ended March 31, 2024 and 2023, the Company recognized interest income of $13,651and $16,688, realized gains of $4,037and $0, and unrealized loss of $706and gain of $38,062, respectively.

Fair Value of Financial Instruments

The Company follows accounting guidelines on fair value measurements for financial instruments measured on a recurring basis, as well as for certain assets and liabilities that are initially recorded at their estimated fair values. Fair Value is defined as the exit price, or the amount that would be received from selling an asset or paid to transfer a liability in an orderly transaction between market participants as of the measurement date. The Company uses the following three-level hierarchy that maximizes the use of observable inputs and minimizes the use of unobservable inputs to value its financial instruments:

	●	Level 1: Observable inputs such as unadjusted quoted prices in active markets for identical instruments.
	●	Level 2: Quoted prices for similar instruments that are directly or indirectly observable in the marketplace.
	●	Level 3: Significant unobservable inputs which are supported by little or no market activity and that are financial instruments whose values are determined using pricing models, discounted cash flow methodologies, or similar techniques, as well as instruments for which the determination of fair value requires a significant judgment or estimation.

Financial instruments measured at fair value are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company's assessment of the significance of a particular input to the fair value measurement in its entirety requires the Company to make judgments and consider factors specific to the asset or liability. The use of different assumptions and/or estimation methodologies may have a material effect on estimated fair values. Accordingly, the fair value estimates disclosed, or initial amounts recorded, may not be indicative of the amount that the Company or holders of the instruments could realize in a current market exchange.

The carrying amounts of the Company's financial instruments including cash and cash equivalents, prepaid expenses, accounts payable and accrued liabilities approximate fair value due to the short-term maturities of these instruments.

Set out below are the Company's financial instruments that are required to be remeasured at fair value on a recurring basis and their fair value hierarchy as of March 31, 2024 and December 31, 2023:

March 31, 2024		Level 1			Level 2			Level 3			Carrying Value
Assets
Marketable Securities:
United States Treasury Bonds		$	2,789,251			$	-			$	-			$	2,789,251
Total Assets		$	2,789,251			$	-			$	-			$	2,789,251
Liabilities
Derivative Liability - Warrants		$	-			$	-			$	214,615			$	-
Derivative Liability - Accelerated feature			-				-				2,035				-
Total Liabilities		$	-			$	-			$	216,650			$	-

December 31, 2023		Level 1			Level 2			Level 3			Carrying Value
Assets
Marketable Securities:
United States Treasury Bonds		$	2,887,215			$	-			$	-			$	2,887,215
Total Assets		$	2,887,215			$	-			$	-			$	2,887,215
Liabilities
Derivative Liability - Warrants		$	-			$	-			$	410,660			$	410,660
Derivative Liability - Accelerated feature			-				-				3,852				3,852
Total Liabilities		$	-			$	-			$	414,512			$	414,512

Derivative Financial Instruments

The Company does not use derivative instruments to hedge exposures to cash flow, market or foreign currency risks. We evaluate all of our financial instruments to determine if such instruments are derivatives or contain features that qualify as embedded derivatives. For derivative financial instruments that are accounted for as liabilities, the derivative instrument is initially recorded at its fair value and is then re-valued at each reporting date, with changes in the fair value reported in the consolidated statements of operations. For our liability classified derivative financial instruments, the Company used a Monte Carlo valuation model to value the derivative instruments at inception and on subsequent valuation dates. For our equity classified derivative financial instruments, we used a Black-Scholes option-pricing model at the grant date to value the derivative instrument. The classification of derivative instruments, including whether such instruments should be recorded as liabilities or as equity, is evaluated at the end of each reporting period. Derivative liabilities are classified in the condensed consolidated balance sheets as current or non-current based on whether or not net-cash settlement or conversion of the instrument could be required within twelve (12) months of the balance sheet date.

Warrants

The Company accounts for warrants as either equity-classified or liability-classified instruments based on an assessment of the warrant's specific terms and applicable authoritative guidance in FASB ASC 480, Distinguishing Liabilities from Equity ("ASC 480") and ASC 815, Derivatives and Hedging ("ASC 815"). The assessment considers whether the warrants are freestanding financial instruments pursuant to ASC 480, meet the definition of a liability pursuant to ASC 480, and whether the warrants meet all of the requirements for equity classification under ASC 815, including whether the warrants are indexed to the Company's own ordinary shares and whether the warrant holders could potentially require "net cash settlement" in a circumstance outside of the Company's control, among other conditions for equity classification. Finally, the Company determines if the warrants meet the definition of a derivative based on their contractual terms. This assessment, which requires the use of professional judgment, is conducted at the time of warrant issuance and as of each subsequent quarterly period end date while the warrants are outstanding.

For issued or modified warrants that meet all of the criteria for equity classification, the warrants are required to be recorded as a component of additional paid-in capital at the time of issuance. For issued or modified warrants that do not meet all the criteria for equity classification, the warrants are required to be recorded at their initial fair value on the date of issuance, and each balance sheet date thereafter. Changes in the estimated fair value of the warrants are recognized as a non-cash gain or loss on the condensed consolidated statements of operations. The Company also evaluates if changes in contractual terms or other considerations would result in the reclassification of outstanding warrants from liabilities to stockholders' equity (or vice versa). The fair value of the warrants is estimated using a Black-Scholes pricing model or a Monte Carlo simulation.

Research and Development Expenses

Research and development expenses are charged to expense as incurred. Research and development expenses include, but are not limited to, product development, clinical and regulatory expenses, payroll and other personnel expenses, which include a certain portion of our chief executive officer, chief operating officer, chief financial officer and directors' compensation. For the three months ended March 31, 2024 and 2023, a portion of personnel-related expenses and stock-based compensation expense for these individuals totaling $165thousand and $385thousand, respectively, was included within research and development due to their active involvement in the research and development activities, materials, supplies, related subcontract expenses, and consulting costs.

Regarding the accounting treatment for reimbursements, GAAP provides limited guidance on the accounting for government grants received by for-profit companies. In accordance with ASC Topic 832, Government Assistance, as adopted January 1, 2022, we disclose certain types of government assistance received in the notes to the consolidated financial statements that includes: a) the nature of the transaction including the nature of the assistance being given, b) the accounting policies being used to account for the transaction and c) other provisions of relevance, where required. Depending on the type of grant or contract, we understand there is more than one acceptable alternative for the accounting treatment - a reduction of costs, a deferred credit to be amortized, revenue or other income. The Company has concluded that reimbursements received for R&D expenses incurred, are more akin to a reduction of costs and applies reimbursements against incurred research costs. There were no reimbursements received for the three months ended March 31, 2024 and 2023.

Net Loss Per Common Stock

Net loss per share of common stock requires presentation of basic earnings per common share on the face of the unaudited condensed consolidated statements of operations for all entities with complex capital structures and requires a reconciliation of the numerator and denominator of the basic earnings per share computation. In the accompanying condensed consolidated financial statements, basic loss per common share is computed by dividing net loss attributable to common stockholders by the weighted average number of shares of common stock outstanding during the year. Diluted earnings per share is computed by dividing net income attributable to common stockholders by the weighted average number of shares of common stock outstanding and potentially dilutive outstanding shares of common stock during the period to reflect the potential dilution that could occur from common shares issuable through convertible securities, contingent share arrangements, stock options and warrants unless the result would be antidilutive.

The dilutive effect of restricted stock units subject to vesting and other stock-based payment awards subject to vesting and common stock warrants is calculated using the "treasury stock method," which assumes that the "proceeds" from the exercise of these instruments are used to purchase common shares at the average market price for the period. The dilutive effect of convertible securities is calculated using the "if-converted method." Under the if-converted method, securities are assumed to be converted at the beginning of the period, and the resulting shares of common stock are included in the denominator of the diluted calculation for the entire period being presented.

For the three months ended March 31, 2024 and 2023, the following common stock equivalents were excluded from the computation of diluted net loss per share as the result of the computation was anti-dilutive.

		March 31,			March 31,
		2024			2023
Convertible notes (Note 6)			107,429				236,641
Warrant (Note 7)			184,000				184,000
Restricted stock units (Note 7)			34,106				2,966
			325,535				423,607

Deferred Offering Costs

Pursuant to ASC 340-10-S99-1, costs directly attributable to an offering of equity securities are deferred and would be charged against the gross proceeds of an offering as a reduction of additional paid-in capital. Deferred offering costs may consist of underwriting, legal, accounting, and other expenses incurred through the balance sheet date that are directly related to a proposed public offering. Should the proposed public offering prove to be unsuccessful, any deferred costs, as well as additional expenses to be incurred, will be expensed.

Recent Accounting Pronouncements

In November 2023, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") No. 2023-07, Segment Reporting Topic 280, "Segment Reporting-Improvements to Reportable Segment Disclosures," which allows disclosure of one or more measures of segment profit or loss used by the chief operating decision maker to allocate resources and assess performance. Additionally, the standard requires enhanced disclosures of significant segment expenses and other segment items, as well as incremental qualitative disclosures on both an annual and interim basis. This guidance is effective for annual reporting periods beginning after December 15, 2023, and interim reporting periods after December 15, 2024. Early adoption is permitted and retrospective application is required for all periods presented. The adoption of this new guidance is not expected to have a significant impact on our consolidated financial statements.

In December 2023, the FASB issued ASU No. 2023-09, Income Taxes Topic 740, "Income Tax-Improvements to Income Tax Disclosures," which requires enhanced disclosures, including specific categories and disaggregation of information in the effective tax rate reconciliation, disaggregated information related to income taxes paid, income or loss from continuing operations before income tax expense or benefit, and income tax expense or benefit from continuing operations. This guidance is effective for annual reporting periods beginning after December 15, 2024. Early adoption is permitted and should be applied on a prospective basis, however retrospective application is permitted. The Company is currently evaluating the impact of adopting this guidance on its consolidated and condensed financial statements and disclosures included within notes to consolidated and condensed financial statements.

Note 4 - Leases

Operating lease right-of-use ("ROU") assets and liabilities are recognized at the present value of the future lease payments as of the lease commencement date. Operating lease expense is recognized on a straight-line basis over the lease term.

During the three months ended March 31, 2023, the Company had a lease agreement which allowed for the use of a laboratory facility for a monthly payment of $6,480. The laboratory lease commenced on October 1, 2018 and expired on October 31, 2023.

The Company currently has a lease agreement which allows for the use of a laboratory facility, entered into on February 16, 2023, with base rent of $7,206per month for a period of 64months, which increases at the rate of 3% per year, that commenced June 1, 2023. The lease included a six-month 50% rent abatement upon commencement. Additional common area maintenance ("CAM") fees are charged monthly and revised annually. The estimated monthly CAM fees are $3,300per month for the first year of the lease, which are being expensed as incurred. An irrevocable letter of credit ("LOC") for the security deposit of $43,234and base rent of $3,891, including 50% abatement, and $3,315of CAM cost, was due and paid on execution of the lease agreement. Alexandria Real Estate (ARE-QRS-CORP) is the beneficiary of the LOC, and the expiry date of the LOC is March 1, 2025.

The following summarizes the right-of use asset and lease information for the Company's operating leases:

		Three Months Ended
		March 31,
		2024			2023
Operating lease cost		$	22,947			$	17,544
Variable lease cost			10,440				-
Sublease income			(2,163	)			(2,121	)
Total lease cost		$	31,224			$	15,423
Other information
Operating cash flows from operating leases		$	22,482			$	19,440
Weighted-average remaining lease term - operating leases (year)			4.42				0.56
Weighted-average discount rate - operating leases			10.48	%			10	%

Future non-cancelable minimum lease payments under the operating lease liability as of March 31, 2024, are as follows:

Years ended December 31,
2024 (excluding the three months ended March 31, 2024)		$	69,020
2025			94,246
2026			97,074
2027			99,986
2028			68,235
Total future minimum lease payments			428,561
Less: imputed interest			(85,407	)
Present value of payments		$	343,154

Note 5 - Notes Payable-Related Party

During the three months ended March 31, 2024 and 2023 the Company incurred $0and $4,237in interest expense. During the three months ended March 31, 2024 and 2023 principal payments of $0and $546,244and accrued interest of $0and $79,044were paid, respectively, on notes to related parties. The principal and accrued interest for these notes were fully paid by December 31, 2023.

Note 6 - Convertible Notes and Notes Payable

Alto Opportunity Master Fund, SPC

On January 11, 2023, the Company entered into a securities purchase agreement (the "SPA") with Alto Opportunity Master Fund, SPC - Segregated Master Portfolio B, a Cayman entity (the "Investor"), pursuant to which the Company sold to the Investor a $4,300,000convertible note (the "Alto Convertible Note") and warrant (the "Warrant") to purchase 127,260shares of common stock, exercisable at $18.80per share, in exchange for gross proceeds of $3,935,000(the "Investment Amount") (See Note 8). The Company determined that the Warrant contains a net cash settlement feature at inception and categorized the Warrant as a liability in the accompanying condensed consolidated financial statements. The Alto Convertible Note matures on March 11, 2025, but may be extended at the option of the noteholder. The Alto Convertible Note amortizes on a monthly basis and the Company can make such monthly amortization payments in cash or, subject to certain equity conditions, in registered shares of common stock or a combination thereof. Installments may be deferred by the noteholder, resulting in a variable interest rate. However, the effective interest rate is approximately 244% based on the internal rate of return calculated on a series of cash flows that occur at regular intervals. For equity repayment, the Alto Convertible Note is convertible into shares of common stock at a price per share equal to the lower of (i) $18.80, (ii) 90% of the three lowest daily VWAPs of the 15 trading days prior to the payment date, or (iii) 90% of the VWAP of the trading day prior to payment date. The noteholder may convert at any time at a fixed price of $18.80 per share.The noteholder has an acceleration of installment amount conversion option (the "Acceleration Option"), whereby the noteholder, with certain share percentage limitations, can convert to common stock any outstanding installment amount at an amount equal to the installment amount plus five times (5x) the installment amount at any time. The Company has determined the Acceleration Option is an embedded derivative within the host instrument and has bifurcated it from the host instrument and recorded it as a derivative liability valued at $1,442,000at inception, using a Monte Carlo simulation model (Note 8). The Convertible Note is repayable over 26 months and bears interest at the rate of 5% per annum. Additionally, the note contains certain redemption options and "Make Whole" provisions.

In conjunction with entry into the SPA, the Company entered into a series of related agreements, including a security agreement (the "Security Agreement"), an intellectual property security agreement (the "IP Security Agreement") and a subsidiary guaranty (the "Subsidiary Guaranty"). The security agreements and guaranty allow, among other things, for the Investor to have a security interest in and place a lien on all of the Company's assets and intellectual property until such time as the Alto Convertible Note is paid off. In addition, the SPA called for the Company to enter into a springing deposit account control agreement (the "Springing DACA"), which, in the event the Company defaults on its repayment of the Alto Convertible Note, would allow the Investor to assume control of the Company's bank account only with regard to any funds remaining outstanding under the Alto Convertible Note. As such, in conjunction with entry into the SPA, the Company established a separate bank account in which it deposited the Investment Amount and pursuant to which the Company, the Investor and the bank holding the Investment Amount, First Republic Bank, entered into the Springing DACA agreement. As the Investment Amount had been held at First Republic Bank, in light of certain banking crises then affecting smaller banks, on March 12, 2023, the Company and the Investor moved the Investment Amount from First Republic Bank, after which time the Springing DACA was no longer in effect. Further, pursuant to amendments to the SPA entered into in May and June of 2023, the Company and the Investor agreed that all of the Investment Amount would be released to the Company and the relevant provision of the SPA which required the Springing DACA would no longer be deemed applicable. In addition, the Company granted the Investor the option to purchase up to an additional $10.0million in convertible notes and warrants on substantially the same terms as the Alto Convertible Note and Warrant, excluding the Springing DACA requirement, with such option to be effective through December 31, 2025. The agreement offers the investor an opportunity to participate in future capital raises at substantially similar terms as the January 11, 2023 agreement. The Company expects that such subsequent convertible notes and warrants would be issued on substantially similar terms as the January 11, 2023 initial agreement, as amended, thus providing the Company the opportunity to negotiate certain aspects of the agreement.

Boustead Securities, LLC ("Boustead") served as a placement agent for the Alto Convertible Note and Warrant offering and received $345,000cash compensation and a warrant to purchase 8,909shares of common stock, exercisable at $18.80per share. The Boustead warrant was determined to be an equity instrument valued on a non-recurring basis. The Company used the Black Scholes valuation model using a term of five years, volatility of 110%, a risk-free rate of 3.53% for a value of $99,543.

The Company allocated the finance costs related to the Boustead placement agent fee of $345,000, based on the relative fair market values of the Convertible Note and warrants issued. The allocation of the financing costs applied $232,027to the debt component as a debt discount that is being amortized to interest expense over the term of the Convertible Note, $104,245to the warrant derivative liability component, expensed as a finance fee, and $8,727to the equity warrant as a reduction in additional paid in capital.

The Company allocated to the debt component of the note an original discount of $300,000, legal fees of $65,000, $215,000for additional interest fees on day one added to note principal, $1,442,000for the accelerated conversion feature, and $1,288,543for the fair value of warrants, resulting in an additional $3,310,543debt discount that is being amortized to interest expense over the term of the Alto Convertible Note.

During the three months ended March 31, 2024, the Company recorded interest expense of $497,515, which included amortization of debt discount as interest expense of $445,509. During the three months ended March 31, 2024, the Company settled $235,200of principal, and settled $18,783of accrued interest, which settlements were made in the form of 78,197shares of common stock, during the three months ended March 31, 2024.

During the three months ended March 31, 2023, the Company recorded interest expense of $599,331, which included amortization of debt discount of $463,052as interest expense and settlement of $20,142of accrued interest and $66,150of principal by issuing 6,375shares of Common Stock.

As of March 31, 2024, the outstanding principal for the convertible note was $2,019,656and the debt discount remaining was $1,078,258, with a net convertible note carrying value of $941,398as of March 31, 2024.

Subsequent to March 31, 2024, the Company and the Investor agreed to certain changes in terms of the Alto Convertible Note as well as the waiver of certain covenant violations. See Subsequent Events for further details.

Note 7 - Stockholders' Equity

Common Stock

During the three months ended March 31, 2024, the Company issued:

●

78,197shares of common stock to settle $235,200of principal and $18,783of interest on a convertible note and incurred $71,315of loss on settlement.

●

15,625shares of common stock issued for vesting of restricted stock units.

During the three months ended March 31, 2023, the Company issued:

●

6,375shares of Common Stock to settle $66,150of principal and $20,142of interest on a convertible note and incurred $18,254of loss on settlement.

Warrants

In connection with the January 2023 Alto Convertible Note, Boustead was granted warrants to purchase 8,909shares of common stock, at an exercise price of $18.80per share (Note 6). In addition, Alto was granted warrants to purchase 127,260shares of common stock, at an exercise price of $18.80per share (Note 6, 8).

A summary of activity regarding all warrants issued for the three months ended March 31, 2024 were as follows:

		Number of			Weighted Average			WeightedAverage
		Warrants			Exercise Price			Life (years)
Outstanding, December 31, 2023			184,000			$	23.20				2.77
Granted			-				-				-
Outstanding, March 31, 2024			184,000			$	23.20				2.53

The intrinsic value of the warrants as of March 31, 2024 is $0. All of the outstanding warrants are exercisable as of March 31, 2024.

Equity Incentive Plan

Our 2018 Equity Incentive Plan (the "2018 Plan") provides for equity incentives to be granted to our employees, executive officers, directors and key advisers and consultants. Equity incentive grants may be made in the form of stock options with an exercise price of not less than the fair market value of the underlying shares as determined pursuant to the 2018 Equity Incentive Plan, restricted stock awards, other stock-based awards, or any combination of the foregoing. The 2018 Equity Incentive Plan is administered by the Company's compensation committee. We have reserved 3,000,000shares of our common stock for issuance under the 2018 Equity Incentive Plan. As of March 31, 2024, 109,773shares have been granted under the 2018 Equity Incentive Plan, of which 75,673shares have vested.

Restricted Stock Units

We may grant restricted stock units ("RSU") under our 2018 Plan. RSUs are bookkeeping entries representing an amount equal to the fair market value of one share of our common stock. Subject to the provisions of our 2018 Plan, the administrator determines the terms and conditions of RSUs, including the vesting criteria and the form and timing of payment. Notwithstanding the foregoing, the administrator, in its sole discretion, may accelerate the time at which any restrictions will lapse or be removed. RSUs granted typically vest annually in one third increments from the date of appointment.

During the three months ended March 31, 2024 and 2023, pursuant to agreements with officers and consultants, 25,000and 0RSUs with a value of $41,840and $0were granted and compensation expense for RSUs of $111,449and $8,333, respectively, was incurred. During the three months ended March 31, 2024 and 2023, $33,953and $0, respectively, was included in compensation under Research and Development.

As of March 31, 2024, there was $161,941of unrecognized RSU compensation cost related to non-vested share-based compensation arrangements which is expected to be recognized over a weighted-average period of 0.92years.

A summary of activity regarding the Restricted Stock Units issued follows:

		Number of RSU			Weighted Average Fair Value Per RSU
Outstanding, December 31, 2023			24,731			$	11.76
Granted			25,000				1.68
Vested			(15,625	)			5.84
Outstanding, March 31, 2024			34,106			$	7.12

Rights Offering and Financing Commitment

On February 7, 2024, the Company and its wholly-owned subsidiary, Shuttle Diagnostics, Inc., entered into a securities purchase agreement (the "Purchase Agreement") with SRO, LLC, a Nevada limited liability company, pursuant to which SRO LLC agreed to commit to purchasing from the Company $2,250,000of units from the Company, with each Unit consisting of (i) one share of the Company's common stock, (ii) a warrant to purchase one share of the Company's common stock exercisable at a purchase price of $18.80 per share, and (iii) a percentage of equity interest in Diagnostics such that, assuming the sale of all $2,250,000 of Units, SRO LLC will own a 22% interest in Diagnostics. Pursuant to the terms of the Purchase Agreement, the Units will be sold at a per Unit price equal to 90% of the VWAP of the Company's common stock for the five trading days immediately preceding closing. The parties entered into the Purchase Agreement in anticipation of the Company commencing a rights offering (the "Rights Offering") pursuant to which the Company intends to offer a total of $4,500,000of Units to existing stockholders, which includes the $2,250,000of Units being sold to SRO LLC, an entity which is controlled by Keith Moore, Executive Chairman of Boustead & Company Limited, an affiliate of Boustead Securities, LLC ("BSL").

The Company filed an initial registration statement on Form S-1 (the "Form S-1") with the SEC in April 2024 related to the registration of subscription rights to purchase the Units to be sold in the Rights Offering. The Form S-1 has not been declared effective as of the date these condensed consolidated financial statements were issued. Upon the Form S-1 being declared effective, the Purchase Agreement allows SRO LLC up to 60 days to raise the initial $2,250,000, which funds will be placed in escrow with Sutter Securities, Inc. ("SSI"), an affiliate of BSL, pursuant to the terms of an escrow agreement entered into between the Company, Shuttle Diagnostics, Inc., BSL and SSI on February 7, 2024 (the "Escrow Agreement"). The funds will remain in escrow up until closing on the Rights Offering. In addition, in the event the Company fails to raise the full $4,500,000in the Rights Offering, SRO LLC agreed to a backstop commitment pursuant to which it would have the right to purchase any remaining Units not purchased by existing Company stockholders in the Rights Offering, up to an additional $2,250,000(the "Back-up Contingency"). Unless the parties waive the conditions to closing, in the event the full $4,500,000 is not raised, whether through SRO LLC or through the Company's existing stockholders, the Company will not close on the offering and any funds raised and held in escrow will be returned to investors.

In conjunction with its entry into the Purchase Agreement, on February 7, 2024, the Company entered into a placement agent and advisory services agreement (the "Placement Agent Agreement") with BSL, pursuant to which BSL and BSL's affiliates will provide the Company with regular and customary financial consulting advice and will act as placement agent, on a best efforts basis, for the Rights Offering. In exchange for its services, BSL will receive a commitment fee equal to $112,500upon the earlier of the Company filing the registration statement on Form S-1 registering the Rights Offering or upon such date as the Company terminates the Rights Offering, a commission equal 8% of the gross proceeds disbursed to the Company upon closing the Rights Offering, and $40,000in diligence and related expenses.

As of March 31, 2024, the Company has incurred $82,000in costs directly related to the planned Rights Offering. The Company has deferred these costs as other current assets in the condensed consolidated balance sheet and will recognize the deferred costs as a reduction in proceeds obtained upon the closing of the Rights Offering, or as an expense in the event the Rights Offering is not consummated.

Note 8 - Derivative Liabilities

Fair Value Assumptions Used in Accounting for Derivative Liabilities

ASC 815 requires us to assess the fair market value of derivative liabilities at the end of each reporting period and recognize any change in the fair market value as other income or expense.

In January 2023, in connection with the Alto Convertible Note, the Company issued warrants to purchase 127,260shares of common stock, with an exercise price of $18.80per share, valued at inception at $1,189,000and as of March 31, 2024, at $214,615. The Company determined our derivative liabilities from the warrants issued in relation to the Alto Convertible Note do not satisfy the classification as equity instruments due to the existence of a certain net cash settlement provision that is not within the sole control of the Company. In addition, there are certain down round provisions that could reduce the exercise price if the Company issues securities at lower prices in the future.

The Company determined our derivative liability from the noteholder's Acceleration Option for the Alto Convertible Note is not clearly and closely related to the host and should be thus accounted for as a bifurcated derivative liability.

The Company classified these derivative liabilities as a Level 3 fair value measurement and used the Monte Carlo pricing model to calculate the fair value as of January 11, 2023 ($2,631,000included in debt discount) and March 31, 2024 ($216,650). Key inputs for the simulation are summarized below. The Monte Carlo simulation uses an implied VWAP for the January 11, 2023 valuation date. The implied VWAP was backsolved by setting the summation of the parts (e.g., derivatives and debt without derivatives) equal to the cash proceeds. The simulation was then iterated and manipulated to solve for the implied share price, which was approximately $12.64per share (or an approximate 14% discount to the quoted market VWAP on January 11, 2023).

The key inputs for the Monte Carlo simulation as of March 31, 2024, were as follows:

Net cash settlement and down round key valuation inputs - warrants*
Annualized volatility			67.19% - 72.53	%
Risk-free interest rate			4.40% - 5.47	%
Quoted VWAP*		$	3.28
Exercise price		$	18.80
Probability assessment			5% - 25	%
Illiquidity discount			(16	)%
Time period (years)			0.17- 2.79

*	Based on a Monte Carlo simulation analysis of 250,000 iterations

Acceleration option key valuation inputs*
Annualized volatility			48.36% - 54.75	%
Risk-free interest rate			4.94% - 5.49	%
Quoted VWAP*		$	3.28
Illiquidity discount			(16	)%
Time period (years)			0- 0.95

*	Based on a Monte Carlo simulation analysis of 250,000 iterations

The following table summarizes the changes in the derivative liabilities:

Fair Value Measurements Using Significant Unobservable Inputs (Level 3)
		Warrants			Accelerated Feature
Balance - December 31, 2023		$	410,660			$	3,852
Gain on change in fair value			(196,045	)			(1,817	)
Balance - March 31, 2024		$	214,615			$	2,035

Note 9 - Related Party Transactions

On September 14, 2022, we entered into a manufacturing agreement with TCG GreenChem, Inc. ("TCG GreenChem"), the U.S. subsidiary of TCG Lifesciences Pvt Ltd., a global contract research and manufacturing services company located in India. Dr. Chis Senanayake, one of our independent directors, is CEO and CSO of TCG GreenChem and CSO of TCG Lifesciences Pvt Ltd. TCG GreenChem was contracted for process research, development and cGMP compliant manufacture of IPdR. During the three months ended March 31, 2024 and 2023, the Company expensed $0and $300,000, respectively.

Note 10 - Subsequent Events

See above Note 2, Restatement of Previously Issued Financial Statements and Note 1, Summary of Significant Accounting Policies, Reverse Stock Split.

Alto Opportunity Master Fund, SPC

On July 12, 2024, the Company informed the Investor in the Alto Convertible Note that the Company's expected restatement of its consolidated financial statements for the years ended December 31, 2022 and 2023 constituted an event of default under the terms of the Alto Convertible Note. On August 6, 2024, the Company paid $600,000to the Investor, which funds will be held as collateral to the balance owed under the Alto Convertible Note, and received a waiver from the Investor related to the default.

Alliance Global Partners

On July 30, 2024, the Company engaged A.G. P./Alliance Global Partners ("AGP") to serve as exclusive underwriter, placement agent or advisor in any public or private offering or financing (as defined, the "Offering") of up to $10million.

Phase II study of Ropidoxuridine

On August 8, 2024, the Company entered into a work order (the "Work Order") with Theradex Systems, Inc., a New Jersey contract research organization ("CRO") for purposes of supporting the Company's Phase II Study of Ropidoxuridine as a Radiation Sensitizing Agent During Radiotherapy in Patients with Newly Diagnosed IDH-Wildtype Glioblastoma with Unmethylated MGMT Promotor." As such, Shuttle Pharma is now in the process of signing up six clinical sites where the clinical studies will be performed - two of which have completed initial site initiation visits and one of which is ready to enroll patients - and where the CRO will oversee such studies.

Under the terms of the Work Order, the CRO will oversee the studies for a period of 53 months (the "Term"), including overseeing and monitoring the regulatory aspects of the Phase II clinical trial, and managing the documentation surrounding the clinical trial in exchange for a fee of approximately $2.3million, payable in stages and based upon services performed during the Term of the study.

Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations

The following Management's Discussion and Analysis should be read in conjunction with our financial statements and the related notes thereto included elsewhere in this Quarterly Report. This discussion has been impacted by the restatement described in the Explanatory Note and in Note 2 of the condensed consolidated financial statements of this Quarterly Report. Certain of the financial and other information provided in this Management's Discussion and Analysis has been updated to reflect the restatement adjustments.

The Management's Discussion and Analysis contains forward-looking statements that involve risks and uncertainties, such as statements of our plans, objectives, expectations, and intentions. Any statements that are not statements of historical fact are forward-looking statements. When used, the words "believe," "plan," "intend," "anticipate," "target," "estimate," "expect," and the like, and/or future-tense or conditional constructions ("will," "may," "could," "should," etc.), or similar expressions, identify certain of these forward-looking statements. These forward-looking statements are subject to risks and uncertainties that could cause actual results or events to differ materially from those expressed or implied by the forward-looking statements in this Quarterly Report. Our actual results and the timing of events could differ materially from those anticipated in these forward-looking statements as a result of several factors including, but not limited to, those noted under "Risk Factors" in this Quarterly Report.

We do not undertake any obligation to update forward-looking statements to reflect events or circumstances occurring after the date of this Quarterly Report, except as required by U.S. federal securities laws.

Overview

Founded by Georgetown University Medical School faculty members, Shuttle Pharmaceuticals Holdings, Inc. (the "Company") is a discovery and development stage pharmaceutical company leveraging our proprietary technology to develop novel therapies that are designed to cure cancer. Originally formed as Shuttle Pharmaceuticals, LLC in 2012, our goal is to extend the benefits of cancer treatments by leveraging insights into cancer therapy with surgery, radiation therapy, chemotherapy and immunotherapy. While there are several therapies being developed with the goal of curing cancer, one of the most effective and proven approaches to this is radiation therapy (RT). We are developing a pipeline of products designed to address the limitations of the current standard of cancer therapies. We believe that our product candidates will enable us to deliver cancer treatments that are safer, more reliable and at a greater scale than that available with the current standard of care.

Operations to date have focused on continuing our research and development efforts to advance Ropidoxuridine clinical testing and improved drug formulation, to advance HDAC6 inhibitor (SP-2-225) preclinical development and explore new SBIR contract work on predictive biomarkers of radiation response, as well as prostate cell lines for health disparities research. We have received Small Business Innovation Research ("SBIR") contract funding from the National Institutes of Health ("NIH") for the aforementioned projects. The clinical development of Ropidoxuridine has shown drug bioavailability and a maximum tolerated dose has been established for use in Phase II clinical trials. TCG GreenChem, Inc. ("TCG GreenChem"), with whom we have contracted for process research, development and cGMP compliant manufacture of IPdR, has successfully completed the manufacturing campaign for the active pharmaceutical ingredient (API) of Ropidoxuridine for use in the Company's upcoming Phase II clinical trial in brain cancer patients undergoing radiation therapy. Shuttle also worked with University of Iowa Pharmaceuticals to develop the formulation and produce the capsules, which have been shipped to contract research organization (CRO) Theradex Oncology for distribution to clinical trial sites. Both activities have now been completed. In addition, Shuttle received approval from the FDA to begin the clinical trial. The FDA made recommendations to expand the clinical trial and we agreed with the recommendation. Meetings with clinical sites to review the protocol documents have occurred and FDA required Institutional Review Board approval has been received from the central internal review board, or IRB. With FDA recommended changes incorporated into the revised protocol, the Company believes it remains on track to commence its Phase II clinical study in the second quarter of 2024. The radiation biomarker project and the health disparities project have been completed and the company is following up with plans for clinical validation and potential commercialization. Changes in operational, administrative, legal and professional expenses related to our operations are set forth in more detail in the discussion below.

Restatement of Previously Issued Consolidated Financial Statements

As previously disclosed in the Company's Quarterly Report on Form 10-Q for the period ended March 31, 2024, filed with the Securities and Exchange Commission ("SEC") on May 13, 2024, following the entry of a cease-and-desist order by the SEC against our former auditor, B.F. Borgers CPA PC ("BF Borgers"), we commenced the re-audit (the "Re-audit") of our financial statements for the year ended December 31, 2022, which had been audited by BF Borgers. Since that time and as a result of the Re-audit, as of July 10, 2024, the Company and the Audit Committee have concluded and informed our current auditor, Forvis, that our audited financial statements for the year ended December 31, 2022 (the "2022 Financial Statements"), our audited financial statements for the year ended December 31, 2023 (the "2023 Financial Statements"), and the quarterly periods included in the Company's Annual Report for the year ended December 31, 2023, and the quarterly report for the period ended March 31, 2024 require restatement and are not reliable.

The accounting errors impacting our 2022 Financial Statements include (i) correcting historical and fiscal 2022 stock compensation transactions; (ii) correcting the initial and subsequent accounting for certain convertible notes, promissory notes and warrants to purchase shares of common stock in fiscal 2022; (iii) correcting the historical and subsequent accounting for the Series A Convertible Preferred Stock in fiscal 2022; (iv) correcting the initial and subsequent accounting for warrants issued with the Series A Convertible Preferred Stock, and (v) correcting the recognition of issuance costs related to the initial public offering in fiscal 2022.

The impact of the accounting errors from the 2022 Financial Statements also impacts the Company's 2023 Financial Statements specific to additional paid in capital and accumulated deficit.

The discussion of financial results presented here is reflective of the restatement adjustments. Refer to Note 2 of the condensed consolidated financial statements included elsewhere in this Quarterly Report for more information on the restatement.

Reverse Stock Split

On August 13, 2024, in order to meet Nasdaq's minimum bid price requirement of $1.00 per share (the "Minimum Bid Price Requirement"), the Company effectuated a 1-for-8 reverse stock split of its issued and outstanding common stock, rounding up to account for any fractional shares (the "Reverse Stock Split"). The Reverse Stock Split had no effect on the Company's authorized shares of common stock or preferred stock. Following the reverse stock split on August 13, 2024, the Company had a total of 2,111,235 shares issued and outstanding (or 2,102,511 on a post-split basis as of March 31, 2024). All share, option, warrant and per share amounts (except our authorized outstanding) have been retroactively restated in these financial statements and related disclosures.

Results of Operations

Comparison of the three months ended March 31, 2024 and 2023

The following table summarizes the results of our operations:

		Three Months Ended
		March 31,
		2024			2023			Change			%
Revenue		$	-			$	-			$	-				-
Operating expenses:
Research and development			586,104				921,801				(335,697	)			(36	)%
General and administrative			324,609				255,355				69,254				27	%
Legal and professional			474,134				367,624				106,510				29	%
Total operating expenses and loss of operations			1,384,847				1,544,780				(159,933	)			(10	)%
Other income (expense):
Interest expense - related parties			-				(4,237	)			4,237				(100	)%
Interest expense			(497,515	)			(599,331	)			101,816				(17	)%
Interest income			21,453				16,688				4,765				29	%
Finance fee			-				(104,245	)			104,245				(100	)%
Change in fair value of derivative liabilities			197,862				1,241,000				(1,043,138	)			(84	)%
Gain on sale of marketable securities			4,037				-				4,037				100	%
Change in fair value of marketable securities			(706	)			38,062				(38,768	)			(102	)%
Loss on settlement of convertible debt			(71,315	)			(18,254	)			(53,061	)			291	%
Total other expense			(346,184	)			569,683				(915,867	)			(161	)%
Net loss		$	(1,731,031	)		$	(975,097	)		(755,934	)			78	%

Research and Development, net of contract expense reimbursements. Total research and development ("R&D") expense was $0.6 million for the three months ended March 31, 2024, as compared to $0.9 million for the three months ended March 31, 2023. The decrease of $0.3 million, or 36%, is primarily related to the Company having completed production of the drug product and waiting for the initiation of trials.

R&D compensation related expenses were $0.3 million in the three months ended March 31, 2024 as compared to $0.6 million in the three months ended March 31, 2023. Compensation related expenses were 56% for the three months ended March 31, 2024, representing a decrease from 61% of total R&D in the three months ended March 31, 2023. Subcontract work made up 34% of total R&D expenses in the three months ended March 31, 2024 and 37% of total R&D expenses during the three months ended March 31, 2023.

General and Administrative Expenses. General and Administrative expenses in the three months ended March 31, 2024 increased by $0.1 million, or 27%, from $0.3 million in the three months ended March 31, 2023. The increase in general and administrative expenses was primarily due to a restricted stock-based grant to an officer of the Company valued at $41,840.

Legal and Professional Expenses. During the three months ended March 31, 2024, legal and professional expenses increased by $0.1 million or 29%. The increase in legal and professional fees was primarily due to increases in our expenses related to our public filing requirements, contracts and financing related work.

Other Income (expense) Other expense was $0.3 million for the three months ended March 31, 2024, which consisted of $0.5 million in interest expense on convertible loans, interest income of $21 thousand, loss on settlement of convertible debt of $71 thousand, change in marketable securities of $4 thousand, and a gain on change in fair value of derivative liabilities of $0.2 million. Other income was $0.6 million for the three months ended March 31, 2023, which consisted of $0.6 million in interest expense on convertible loans, $4 thousand in interest expense on related party loans, interest income of $17 thousand, finance fee on convertible loans of $0.1 million, loss on settlement of convertible debt of $18 thousand, unrealized gain on marketable securities of $38 thousand, and a gain on change in fair value of derivative liability of $1.2 million. The $1.0 million gain in fair value of derivative liability resulted from the fair value measurement using the Monte Carlo pricing model and the impact of the decrease in the market price of warrant shares.

Liquidity and Capital Resources

Our condensed consolidated financial statements are prepared on a going concern basis, which contemplates the realization of assets and the satisfaction of liabilities and commitments in the normal course of business. The Company has incurred losses since inception and had a net loss of approximately $1.7 million and no revenues for the three months ended March 31, 2024 and has working capital of approximately $2.9 million as of March 31, 2024. In addition, the convertible note payable outstanding at March 31, 2024 includes covenants and certain cash payment requirements. These conditions, and the Company's ability to comply with such conditions, raise substantial doubt about the Company's ability to continue as a going concern within one year after the date that the condensed consolidated financial statements are issued.

In September 2022, the Company completed its IPO, generating net proceeds of approximately $10.0 million. Additionally, in January 2023, the Company entered into a securities purchase agreement with an institutional investor through which the Company sold a convertible note with a principal value of $4.3 million, along with a four-year warrant to purchase 127,260 shares of common stock, exercisable at $18.80 per share, providing the Company with approximately $3.6 million in net proceeds. To date, the warrant has not yet been exercised. However, the Company's existing cash resources, marketable securities and the cash received from the equity offering and convertible note are not expected to provide sufficient funds to carry out the Company's operations and clinical trials through the next twelve months.

The IPO and subsequent capital raise have supported operations leading up to the manufacture of drug product and FDA approval of the IND for the Phase II clinical trial of Ropidoxuridine and radiation therapy in glioblastoma. The FDA recommended and the Company agreed to an expansion of the clinical trial, necessitating additional capital to complete the trial as well as fund ongoing operations. As a result, management initiated a $4.5 million rights offering and submitted an application for a Small Business Innovation Research ("SBIR") grant for non-dilutive funding for pre-clinical project through the National Institutes of Health ("NIH"). The Phase II clinical trial was also approved by the Institutional Review Board "IRB" in June, 2024. In August 2024, the Company took action to pursue a separate capital raise of up to $10 million and entered into a work order with a contract research organization ("CRO") for purposes of supporting the Company's Phase II Study of Ropidoxuridine. Under the terms of the work order, the CRO will oversee the studies for a period of 53 months in exchange for a fee of approximately $2.3 million, payable in stages and based upon services performed during the study. The ability of the Company to continue as a going concern is dependent upon its ability to successfully raise additional equity or debt financing to allow it to fund ongoing operations, conduct clinical trials and bring a drug candidate to commercialization to generate revenues.

The accompanying condensed consolidated financial statements do not include any adjustments to reflect the future effects on the recoverability and classification of assets or the amounts and classification of liabilities if the Company is unable to continue as a going concern.

Balance Sheet Data:

		March 31,			December 31,
		2024			2023			Change			%
Current assets		$	4,411,019			$	5,593,005			$	(1,181,986	)			(21	)%
Current liabilities			1,489,217				1,042,237				446,980				43	%
Working capital		$	2,921,802			$	4,550,768			$	(1,628,966	)			(36	)%

As of March 31, 2024, total current assets were $4.4 million and total current liabilities were $1.5 million, resulting in working capital of $2.9 million. As of December 31, 2023, total current assets were $5.6 million and total current liabilities were $1.0 million, resulting in a working capital of $4.6 million. As of March 31, 2024, the current assets primarily resulted from $1.4 million cash and $2.8 million marketable securities, with the decrease from December 31, 2023 being primarily due to ongoing cash burn from our R&D programs, filing expenses and general operations. The increase in current liabilities is primarily due to the current portion of the $4,300,000 convertible note and accrued interest that increased $0.4 million and an increase in accounts payable of $65 thousand.

Cash Flows from Operating Activities

		Three Month Ended
		March 31,
		2024			2023			Change			%
Cash used in operating activities		$	(1,239,083	)		$	(1,337,982	)		$	98,899				(7	)%
Cash used in investing activities		$	101,295			$	(2,953,709	)		$	3,055,004				(103	)%
Cash provided by financing activities		$	(40,000	)		$	3,043,756			$	(3,083,756	)			(101	)%
Cash on hand		$	1,398,628			$	7,169,268			$	(5,770,640	)			(80	)%

To date, we have not generated positive cash flows from operating activities. For the three months ended March 31, 2024, net cash flows used in operating activities was $1.2 million, consisting of a net loss of $1.7 million, increased by a gain on change in derivative liabilities of $0.2 million, offset by amortization of debt discount of $0.4 million, loss on settlement of convertible debt of $71 thousand, accrued interest settled with common stock of $19 thousand, stock-based compensation of $111 thousand and increased by a net change in working capital of $50 thousand. For the three months ended March 31, 2023, net cash flows used in operating activities was $1.3 million, consisting of a net loss of $1.0 million, increased by a gain on change in derivative liability of $1.2 million, offset by amortization of debt discount of $0.6 million, and further reduced by a net change in working capital of $0.3 million.

Cash Flows from Investing Activities

For the three months ended March 31, 2024, we invested in trading marketable securities for $19 thousand and received $120 thousand in proceeds from disposition of marketable securities. For the three months ended March 31, 2023, we invested in trading marketable securities for $3.0 million.

Cash Flows from Financing Activities

For the three months ended March 31, 2024, we paid $40,000 related to financing activities. For the three months ended March 31, 2023, we received a net of $3,590,000 from the sale and issuance of convertible notes payable and warrants and repaid $546,244 in related party notes payable.

Off-Balance Sheet Arrangements

We do not have any off-balance sheet arrangements that have or are reasonably likely to have a current or future effect on our financial condition, changes in financial condition, revenues or expenses, results of operations, liquidity, capital expenditures or capital resources that are material to investors.

Critical Accounting Policies and Significant Judgments and Estimates

This discussion and analysis of our financial condition and results of operations is based on our condensed consolidated financial statements, which have been prepared in accordance with generally accepted accounting principles in the United States ("GAAP"). The preparation of these condensed consolidated financial statements requires us to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements, as well as the reported expenses incurred during the reporting periods. Our estimates are based on our historical experience and on various other factors that we believe are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Actual results may differ from these estimates under different assumptions or conditions. While our significant accounting policies are described in more detail in the notes to our condensed consolidated financial statements included elsewhere in this report, we believe that the following accounting policies are critical to understanding our historical and future performance, as these policies relate to the more significant areas involving management's judgments and estimates.

Our most critical accounting policies and estimates relate to the following:

	●	Initial Measurement of Equity-Based Warrants
	●	Research and Development Expenses
	●	Fair Value of Derivative Financial Instruments

Initial Measurement of Equity-Based Warrants

We evaluate all of our financial instruments to determine if such instruments are derivatives or contain features that qualify as embedded derivatives. For derivative financial instruments that are accounted for as equity, the derivative instrument is initially recorded at its fair value and recorded to additional paid in capital. The classification of derivative instruments, including whether such instruments should be recorded as equity, is evaluated at the end of each reporting period.

For our derivative financial instruments classified as equity, the Company used a Black Scholes valuation model, to calculate the fair value on issuance date, without revaluation.

The use of Black Scholes valuation model requires the input of highly subjective assumptions, including the expected price volatility, that is based on an analysis of the historical volatility of the common stock of a group of comparable entities. Any change to these inputs could produce significantly higher or lower fair value measurements.

Research and Development

Research and development expenses are expensed as incurred and, prior to our initial public offering in September 2022, have historically been offset by contract receivable payments from an NIH SBIR contract that has supported our scientific research. This is stated in the financials as research and development-net of contract expense reimbursements.

Fair Value of Financial Instruments

We evaluate all of our financial instruments to determine if such instruments are derivatives or contain features that qualify as embedded derivatives. For derivative financial instruments that are accounted for as liabilities, the derivative instrument is initially recorded at its fair value and is then re-valued at each reporting date, with changes in the fair value reported in the condensed consolidated statements of operations. The classification of derivative instruments, including whether such instruments should be recorded as liabilities are evaluated at the end of each reporting period.

For our derivative financial instruments classified as a liability, the Company utilizes Monte Carlo or other appropriate valuation models to value the derivative instruments at inception and on subsequent valuation dates. The model requires the use of simulations that are weighted based on significant unobservable inputs including the average volatility of a population set and probabilities assigned. Each simulation is based on the range of inputs in a scenario with the mean of the output on each simulation calculated as an average. The Monte Carlo simulation uses an implied VWAP for valuation. The implied VWAP was backsolved by setting the summation of the parts (e.g., derivatives and debt without derivatives) equal to the cash proceeds and is updated each period.

The use of Monte Carlo valuation models require key inputs, some of which are based on estimates and judgements by management. Any change to these key inputs could produce significantly higher or lower fair value measurements.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

As a "smaller reporting company," we are not required to provide the information required by this Item.

Item 4. Controls and Procedures

Evaluation of Disclosure Controls and Procedures

Disclosure controls and procedures (as defined in Exchange Act Rule 15d-15(e)) are designed with the objective of ensuring that information required to be disclosed in our reports filed under the Exchange Act, such as this report, is recorded, processed, summarized, and reported within the time periods specified in the SEC's rules and forms. Disclosure controls and procedures are also designed with the objective of ensuring that such information is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure.

As of March 31, 2024, our management carried out an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures. Such evaluation was carried out under the supervision of our Chief Executive Officer with the participation of our President and Chief Operating Officer, our Chief Financial Officer, and our third party financial service provider. Based on this evaluation, management concluded that our disclosure controls and procedures were, and continue to be, ineffective as of March 31, 2024. Based on the foregoing, our management concluded that our internal controls over the following financial reporting areas to be material weaknesses:

	●	Our written accounting policies and documentation of management's contemplation of the accounting treatment and implications over significant unusual transactions, including complex accounting associated with debt and equity transactions, was limited and resulted in ineffective monitoring of financial reporting. These were contributing factors which lead to untimely filings
	●	Due to our size and stage of development, segregation of all conflicting duties may not always be possible and may not be economically feasible. During the year, we lacked sufficient review procedures and segregation of duties such that a proper review had not been performed by someone other than a preparer, including manual journal entries, and that process documentation is lacking for review and monitoring controls over financial statements close process and financial reporting.
	●	As a result of the Company's evolution since the date of our initial formation, when we were focused on NIH SBIR research contracts with related costing allocation allowances until when we completed our IPO and continued our development process, management has lacked a formal process to identify and properly classify operating expenses such as Research and Development ("R&D").
	●	We identified findings related to overall information technology general controls ("ITGCs") including issues with access and segregation of duties for systems supporting the Company's internal control processes and controls.
	●	Our accounting policies and oversight regarding certain technical aspects of financial reporting for stock-based compensation transactions, particularly relating to grant date valuations and expense attribution, was also limited and resulted in the incorrect recording of related compensation expense and related disclosures.

There has been no change in the Company's internal control over financial reporting during the three months ended March 31, 2024 that has materially affected, or is reasonably likely to materially affect, the company's internal control over financial reporting. Management will continue to monitor and evaluate the effectiveness of our internal controls and procedures over financial reporting on an ongoing basis and is committed to taking further action and implementing additional improvements as necessary.

Management's Remediation Measures

The aforementioned material weaknesses were identified in 2023 and the ineffective monitoring of financial reporting weakness resulted in the Company needing to restate its 2023 and 2022 financial statements. While the Company has improved its organizational capabilities, the Company's remediation efforts will continue to take place. Management is committed to maintaining a strong internal control environment. In response to the identified material weaknesses in the overall control environment, management is currently implementing additional measures which include:

●	Hired a new Chief Financial Officer ("CFO") during the second quarter of 2024 to bolster the Company's internal technical accounting and financial reporting experience and provide bandwidth for the prior CFO to focus on the Company's expanding clinical trial.
●	Engaged a third-party consulting firm to assist with the preparation of SEC reporting and other technical accounting matters.

The Company will continue to review and improve its internal controls over financial reporting to address the underlying causes of the material weaknesses and control deficiencies. Such material weaknesses and control deficiencies will not be fully remediated until the Company has concluded that its internal controls are operating effectively for a sufficient period of time.

PART II - OTHER INFORMATION

ITEM 1. LEGAL PROCEEDINGS

Currently, there are no legal proceedings pending or threatened against us. We are not presently party to any pending or other threatened legal proceedings or claims that we believe will have a material adverse effect on our business, financial condition or operating results, although from time to time, we may become involved in legal proceedings in the ordinary course of business.

ITEM 1A. RISK FACTORS

As a smaller reporting company, we are not required to provide the information required by this item.

ITEM 2. UNREGISTERED SALES OF SECURITIES AND USE OF PROCEEDS

None.

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

Not Applicable.

ITEM 4. MINE SAFETY DISCLOSURES

Not Applicable.

ITEM 5. OTHER INFORMATION

None.

Item 6. Exhibits

The following exhibits are filed or furnished with this report:

Exhibit No.		Description of Exhibit
3.1		Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Registration Statement on Form S-1 (File No. 333-265429) filed on June 3, 2022).
3.2		Certificate of Amendment to Amended and Restated Certificate of Incorporation, effective March 30, 2022 (incorporated by reference to Exhibit 3.2 to the Registration Statement on Form S-1 (File No. 333-265429) filed on June 3, 2022).
3.3		Certificate of Amendment to Amended and Restated Certificate of Incorporation, effective June 22, 2022 (incorporated by reference to Exhibit 3.5 to the Registration Statement on Form S-1/A (File No. 333-265429) filed on June 23, 2022).
3.4		Second Amended and Restated By-Laws (incorporated by reference to Exhibit 3.1 to the current Report on Form 8-K filed on November 1, 2022).
3.5		Certificate of Amendment to Amended and Restated Certificate of Incorporation, effective August 13, 2024 (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed on August 7, 2024).
4.1		Form of Convertible Note, dated January 11, 2023, issued by Shuttle Pharmaceuticals Holdings, Inc. to Alto Capital Master Fund, SPC - Segregated Master Portfolio B (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed January 12, 2023).
4.2		Form of Warrant, dated January 11, 2023, issued by Shuttle Pharmaceuticals Holdings, Inc. to Alto Capital Master Fund, SPC - Segregated Master Portfolio B (incorporated by reference to Exhibit 10.3 to the Current Report on Form 8-K filed January 12, 2023).
10.1		Asset Purchase Agreement, dated January 30, 2024, by and between Shuttle Pharmaceuticals Holdings, Inc., Alan Kozikowski and Werner Tueckmantel (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on February 5, 2024).
10.2		Securities Purchase Agreement, dated February 7, 2024, between Shuttle Pharmaceuticals Holdings, Inc., Shuttle Diagnostics, Inc. and SRO, LLC (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on February 13, 2024).
10.3		Placement Agent and Advisory Services Agreement, dated February 7, 2024, between Shuttle Pharmaceuticals Holdings, Inc. and Boustead Securities, LLC (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed on February 13, 2024).
10.4		Offering Deposit Account Agency Agreement, dated February 7, 2024, between Shuttle Pharmaceuticals Holdings, Inc., Boustead Securities, LLC and Sutter Securities Inc. (incorporated by reference to Exhibit 10.3 to the Current Report on From 8-K filed on February 13, 2024).
10.5		Amendment Agreement, dated August 6, 2024, between Shuttle Pharmaceuticals Holdings, Inc., Suttle Pharmaceuticals, Inc. and Alto opportunity Master Fund, SPC - Segregated Master Portfolio B (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on August 7, 2024).
10.6		Work Order, dated August 8, 2024, between Shuttle Pharmaceuticals, Inc. and Theradex Systems, Inc. (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on August 14, 2024).
10.7		Master Services Agreement, dated November 1, 2018, between Shuttle Pharmaceuticals, Inc. and Theradex Systems, Inc. (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed on August 14, 2024).
31.1		Certification of Chief Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.*
31.2		Certification of Chief Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.*
32.1		Certification of Chief Executive Officer Pursuant to 18 U.S.C. Section 1350, As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.**
32.2		Certification of Chief Financial Officer Pursuant to 18 U.S.C. Section 1350, As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.**
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* Filed herewith.

**Furnished herewith.

SIGNATURES

In accordance with the requirements of the Exchange Act, the registrant caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

	SHUTTLE PHARMACEUTICALS HOLDINGS, INC.
September 3, 2024	By:	/s/ Anatoly Dritschilo
		Anatoly Dritschilo, M.D.
		Chief Executive Officer
September 3, 2024	By:	/s/ Timothy J. Lorber
		Timothy J. Lorber Chief Financial Officer

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