Initial Statement of Beneficial Ownership - Form 3

Ownership Submission

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * Abate Kristin 2. Date of Event Requiring Statement (Month/Day/Year) 2024-11-06 3. Issuer Name and Ticker or Trading Symbol Karyopharm Therapeutics Inc. [KPTI] (Last) (First) (Middle) C/O KARYOPHARM THERAPEUTICS INC. , 85 WELLS AVENUE 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) Chief Accounting Officer / 5. If Amendment, Date Original Filed (Month/Day/Year) (Street) NEWTON MA 02459 6. Individual or Join/Group Filing (Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security 2. Amount of Securities Beneficially Owned 3. Ownership Form: Direct (D) or Indirect (I) 4. Nature of Indirect Beneficial Ownership

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivate Security	2. Date Exercisable and Expiration Date	3. Title and Amount of Securities Underlying Derivative Security	4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)	6. Nature of Indirect Beneficial Ownership
Date Exercisable	Expriation Date	Title	Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
Director	10% Owner	Officer	Other
Abate Kristin C/O KARYOPHARM THERAPEUTICS INC. 85 WELLS AVENUE NEWTON, MA02459			Chief Accounting Officer

Signatures

Nancy Smith, Attorney-in-Fact for Kristin Abate	2024-11-22
**Signature of Reporting Person	Date

Explanation of Responses:

(*)	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
(**)	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Includes 87,978 restricted stock units ("RSUs") which were unvested as of November 6, 2024. RSUs convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis.

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