Management Change/Compensation Form 8 K

Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

Departure of Directors

On August 28, 2024, James Healy, M.D., Ph.D., notified Bolt Biotherapeutics, Inc. (the "Company") of his resignation as a member of the Company's Board of Directors (the "Board") and the committees thereof, effective as of September 3, 2024. Dr. Healy's resignation is not the result of any disagreement with the Company relating to the Company's operations, policies or practices.

On September 1, 2024, Frank D. Lee notified the Company of his resignation as a member of the Board and the committees thereof, effective as of September 3, 2024. Mr. Lee's resignation is not the result of any disagreement with the Company relating to the Company's operations, policies or practices.

Appointment of Director

Effective September 3, 2024, the Board appointed Jakob Dupont, M.D., Ph.D., to serve as a Class II member of the Board. Dr. Dupont's term of office as a Class II member will expire at the Company's 2026 annual meeting of stockholders.

Dr. Dupont, age 59, has served as an Executive Venture Partner, Private Equity at Sofinnova Investments since May 2023. Prior to joining Sofinnova, Dr. Dupont was Global Head of Research & Development and Executive Vice President at Atara Biotherapeutics, Inc. from May 2020 to May 2023, where he led the development and approval of EBVallo. Dr. Dupont also served as Chief Medical Officer at Gossamer Bio, Inc. from December 2018 to May 2020 and as Vice President and Global Head of Breast and Gynecologic Cancer Development for Genentech, Inc. from January 2017 to December 2018. Dr. Dupont has also made significant contributions to numerous drug approvals including Herceptin, Perjeta, Kadcyla, Tecentriq, and Avastin. Dr. Dupont serves as a Board Member for Pyxis Oncology, Inc. and for Imugene Limited. Dr. Dupont earned his bachelor's degree from Vassar College, his master's degree from New York University, and his M.D. from the Joan & Sanford I. Weill Medical College of Cornell University.

In accordance with the Company's non-employeedirector compensation policy as described in the Company's definitive proxy statement filed with the Securities and Exchange Commission (the "Commission") on April 26, 2024. Dr. Dupont's compensation for his services as a non-employeedirector will be consistent with that of the Company's other non-employeedirectors, subject to pro-rationto reflect the commencement date of his service on the Board. In addition, Dr. Dupont will enter into the Company's standard form of indemnification agreement, which is filed as Exhibit 10.8 to the Company's Registration Statement on Form S-1(No. 333-252136)as filed with the Commission on January 15, 2021.

Dr. Dupont is not a party to any transaction that would require disclosure under Item 404(a) of Regulation S-K.