Prospectus Certification by Investment Company - Form 497J

FEDERATED HERMES MDT SERIES

4000 Ericsson Drive
Warrendale, Pennsylvania 15086-7561

September 27, 2024

EDGAR Operations Branch
U.S. Securities and Exchange Commission
Division of Investment Management
100 F Street, N.E.
Washington, DC 20549

RE:	FEDERATED HERMES MDT SERIES (the "Registrant")
	Federated Hermes MDT All Cap Core Fund Class A Shares Class C Shares Institutional Shares Class R6 Shares Federated Hermes MDT Balanced Fund Class A Shares Class C Shares Institutional Shares Class R6 Shares Federated Hermes MDT Large Cap Growth Fund Class A Shares Class C Shares Institutional Shares Class R6 Shares Federated Hermes MDT Small Cap Core Fund Class A Shares Class C Shares Institutional Shares Class R6 Shares Federated Hermes MDT Small Cap Growth Fund Class A Shares Class C Shares Institutional Shares Class R6 Shares (collectively, the "Funds")
	1933 Act File No. 333-134468 1940 Act File No. 811-21904

Dear Sir or Madam:

Pursuant to Rule 497(j) under the Securities Act of 1933, as amended (the "1933 Act"), the above-named Registrant hereby certifies that the definitive forms of Prospectuses and Statements of Additional Information dated September 30, 2024, that otherwise would have been filed under Rule 497(c) under the 1933 Act, do not differ from the forms of Prospectuses and Statements of Additional Information contained in the Registration Statement for the Fund(s) which was electronically filed pursuant to Rule 485(b) as Post-Effective Amendment No. 41 on September 25, 2024.

If you have any questions on the enclosed material, please contact Allison Miller at [email protected] or (412) 288-8652.

Very truly yours,

/s/George F. Magera
George F. Magera
Assistant Secretary

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