Brain tumour researcher awarded €1.5m European Research Council grant

A University of Galway researcher whose work focuses on therapies for cancers of the brain has been awarded a prestigious €1.5million grant by the European Research Council.

Dr Catalina Vallejo Giraldo is based at CÚRAM Research Centre for Medical Devices, funded by Taighde Éireann - Research Ireland, at the University, where her research combines biomaterials, brain mechanobiology and medicine to develop new targeted brain treatments.

Dr Vallejo Giraldo's €1.5million award is an ERC Starting Grant - given to talented early-career scientists who are embarking on independent work and show clear potential to be a research leader.

Her current research is investigating cell-cell interactions in the brain and how they are influenced by the interplay within the cell environment, as well as altering the signals in the brain that manipulate cell fate. This research has the potential to develop and improve neuro-oncology therapies.

The ERC Starter Grant will allow Dr Vallejo Giraldo to focus on the development of a new cancer therapy using a soft gel that contains a cancer fighting drug and is patterned with narrow channels to encourage the entry of cancer cells. Once inside, the cancer cells become trapped and compressed, disrupting their DNA repair mechanisms and rendering them susceptible to damage. This approach will improve drug-radiation effectiveness and allow localised therapy of brain cancer.

Dr Catalina Vallejo Giraldo said: "Available drugs are only partially effective, and they work by damaging cancer cell DNA in combination with radiotherapy. In response, cancer cells ramp-up DNA repair processes, rendering these treatments largely ineffective. Mechanical deformation of the nucleus may transiently render cells highly susceptible to DNA damage and may represent a powerful adjunct approach for the treatment of brain tumours, where resistance to conventional DNA-targeting therapies is a significant contributor to therapy failure."

Dr Vallejo Giraldo's PhD training under Professor Manus Biggs, University of Galway lecturer and researcher at CÚRAM, and subsequent postdoctoral work, have given her the experience of interacting with and leading multidisciplinary teams that involve members from academia, industry and the clinic including Universidad EIA, Colombia; Imperial College London; Cardiff University, UK; Neurent Medical, Galway; and the Mayo Clinic in the US.

Dr Vallejo Giraldo added: "This is an enormous opportunity to work on a project I have been building towards for the last few years while training talented PhD students and post-doctoral researchers. I am exceptionally fortunate and grateful to have found great support from collaborators and mentors around the globe, as well as from University of Galway, CÚRAM, the different research centres, and my Biomedical Engineering discipline. I am particularly grateful to Dr Manus Biggs for his continued support."

Professor Biggs said: "The research that Dr Vallejo Giraldo will carry out with the support of this grant builds upon her previous work on neural biomaterials. Her findings have revealed a crucial necessity to expand upon our current understanding of the fundamentals of the mechanobiology of neural cells to develop novel biomaterials platforms that will expediate clinical translation pathways. I'm extremely proud of what she has been able to accomplish and look forward to Catalina making a significant impact with her future work."

Professor Abhay Pandit, Scientific Director of CÚRAM, said: "We are immensely proud of Dr Vallejo Giraldo and all of our graduates and their accomplishments in both academia and industry. CÚRAM provides high-quality training opportunities that is of great importance to the medtech talent pipeline, and our graduates are adding significantly to Ireland's research environment. The interdisciplinary nature of Dr Vallejo Giraldo's work is an excellent example of how CÚRAM works to foster collaboration and excellence in research."

EU Research Commissioner Iliana Ivanova said: "The European Commission is proud to support the curiosity and passion of our early-career talent under our Horizon Europe programme. The new ERC Starting Grants winners aim to deepen our understanding of the world. Their creativity is vital to finding solutions to some of the most pressing societal challenges. In this call, I am happy to see one of the highest shares of female grantees to date, a trend that I hope will continue. Congratulations to all!"

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