Quarterly Report for Quarter Ending September 30, 2024 (Form 10-Q)

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 10-Q

☒	QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2024

OR

☐	TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from ______________ to _______________

Commission file number: 000-56257

ACCUSTEM SCIENCES, INC.

(Exact name of registrant as specified in Its Charter)

Delaware		87-3774438
(State of other jurisdiction of incorporation or organization)		(I.R.S. Employer Identification No.)

5 Penn Plaza, 19th Floor, #1954 New York, NY		10001
(Address of principal executive offices)		(Zip Code)

Registrant's telephone number, including area code: 00 44 2074952379

Securities registered pursuant to Section 12(b) of the Act: None

Securities registered pursuant to Section 12(g) of the Act:

Title of each class		Trading Symbol(s)		Name of each exchange on which registered
Common Stock		ACUT		OTCQB Venture Marketplace ("OTCQB")

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes☒ No ☐

Indicate by check mark whether the Registrant has submitted electronically, every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes☒ No ☐

Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b 2 of the Exchange Act.

Large accelerated filer	☐	Accelerated filer	☐
Non-accelerated filer	☒	Smaller reporting company	☒
		Emerging growth company	☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b 2 of the Exchange Act). Yes ☐ No ☒

As of November 18, 2024, there were 11,346,535shares of Common Stock, $0.001par value outstanding.

Table of Contents

		Page
PART I- FINANCIAL INFORMATION	1
Item 1.	Financial Statements	1
	Condensed Consolidated Balance Sheets as of September 30, 2024 (Unaudited) and December 31, 2023	1
	Unaudited Condensed Consolidated Statements of Operations for the Three and Nine Months Ended September 30, 2024 and 2023	2
	Unaudited Condensed Statements of Changes in Stockholders' Deficit for the Three and Nine Months Ended September 30, 2024 and 2023	3
	Unaudited Condensed Consolidated Statements of Cash Flows for the Nine Months Ended September 30, 2024 and 2023	5
	Notes to Unaudited Condensed Consolidated Financial Statements	6
Item 2.	Management's Discussion and Analysis of Financial Condition and Results of Operations	14
Item 3.	Quantitative and Qualitative Disclosures about Market Risk	19
Item 4.	Controls and Procedures	19
PART II - OTHER INFORMATION	20
Item 1.	Legal Proceedings	20
Item 1A.	Risk Factors	20
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	20
Item 3.	Defaults Upon Senior Securities	20
Item 4.	Mine Safety Disclosures	20
Item 5.	Other Information	20
Item 6.	Exhibits	21
SIGNATURES	22

PART I - FINANCIAL INFORMATION

Item 1. Financial Statements

The accompanying condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles for interim financial information which are the accounting principles that are generally accepted in the United States of America and in accordance with the instructions for Form 10-Q. Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements.

In the opinion of management, the condensed consolidated financial statements contain all material adjustments, consisting only of normal recurring adjustments necessary to present fairly the financial condition, results of operations and cash flows of the Company for the interim periods presented.

The results for the period ended September 30, 2024 are not necessarily indicative of the results of operations for the full year. These financial statements and related notes should be read in conjunction with the consolidated financial statements and notes thereto included in our audited consolidated financial statements for the fiscal years December 31, 2023 and 2022 included in our annual report on Form 10-K filed with the US. Securities and Exchange Commission (the "SEC") on March 22, 2024.

ACCUSTEM SCIENCES INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED BALANCE SHEET

(UNAUDITED)

		September 30, 2024			December 31, 2023
ASSETS
Current Assets
Cash		$	37,080			$	21,481
Prepaid expenses			65,414				108,368
Other Current Assets							-
Total Current Assets			102,494				129,849
Equipment, net			1,325				4,048
TOTAL ASSETS		$	103,819			$	133,897
LIABILITIES AND STOCKHOLDERS' EQUITY
Current Liabilities
Accounts payable		$	790,241			$	578,378
Related party payable			2,285,562				1,454,986
Accrued expenses			164,053				156,434
Note Payable			57,597				55,679
Total Current Liabilities			3,297,453				2,245,477
TOTAL LIABILITIES			3,297,453				2,245,477
Stockholders' Equity
Preferred stock $.001par value; 10,000,000shares authorized; noneissued and outstanding			-				-
Common stock $.001par value; 150,000,000shares authorized; 11,346,535shares issued and outstanding as of September 30, 2024 and December 31, 2023, respectively			11,346				11,346
Additional paid-in capital			4,449,966				4,399,019
Accumulated deficit			(7,654,946	)			(6,521,945	)
TOTAL STOCKHOLDERS' EQUITY			(3,193,634	)			(2,111,580	)
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY		$	103,819			$	133,897

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

ACCUSTEM SCIENCES INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(UNAUDITED)

		Three Months Ended September 30			Nine Months Ended September 30
		2024			2023			2024			2023
OPERATING EXPENSES
Research and development expenses		$	31,409			$	19,951			$	96,352			$	50,128
General and administrative expenses			296,765				578,574				1,036,649				1,754,494
Total operating expenses			328,174				598,525				1,133,001				1,804,622
LOSS FROM OPERATIONS			(328,174	)			(598,525	)			(1,133,001	)			(1,804,622	)
LOSS, BEFORE TAX			(328,174	)			(598,525	)			(1,133,001	)			(1,804,622	)
Income tax benefit (expense)							-								-
NET LOSS		$	(328,174	)		$	(598,525	)		$	(1,133,001	)		$	(1,804,622	)
Net loss per share attributable to common stockholders, basic and diluted		$	(0.03	)		$	(0.05	)		$	(0.10	)		$	(0.16	)
Weighted average common shares outstanding used in computing net loss per share attributable to common stockholders, basic and diluted			11,346,535				11,346,535				11,346,535				11,346,535

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

ACCUSTEM SCIENCES INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY

(UNAUDITED)

For Three Months Ended September 30, 2024

		Common Stock			Additional
		Number of Shares			Amount			Paid-in Capital			Accumulated Deficit			Stockholders' Deficit
Balance at June 30, 2024			11,346,535			$	11,346			$	4,431,120			$	(7,326,772	)		$	(2,884,306	)
Share-based compensation			-				-				18,846				-				18,846
Net loss			-				-				-				(328,174	)			(328,174	)
Balance at September 30, 2024			11,346,535			$	11,346			$	4,449,966			$	(7,654,946	)		$	(3,193,634	)

For Three Months Ended September 30, 2023

		Common Stock			Additional
		Number of Shares			Amount			Paid-in Capital			Accumulated Deficit			Stockholders' Equity
Balance at June 30, 2023			11,346,535			$	11,346			$	4,359,220			$	(5,677,378	)		$	(1,306,812	)
Share-based compensation			-				-				19,900				-				19,900
Net loss			-				-				-				(598,525	)			(598,525	)
Balance at September 30, 2023			11,346,535			$	11,346			$	4,379,120			$	(6,275,903	)		$	(1,885,437	)

For Nine Months Ended September 30, 2024

		Common Stock			Additional
		Number of Shares			Amount			Paid-in Capital			Accumulated Deficit			Stockholders' Deficit
Balance at December 31, 2023			11,346,535			$	11,346			$	4,399,019			$	(6,521,945	)		$	(2,111,580	)
Share-based compensation			-				-				50,947				-				50,947
Net loss			-				-				-				(1,133,001	)			(1,133,001	)
Balance at September 30, 2024			11,346,535			$	11,346			$	4,449,966			$	(7,654,946	)		$	(3,193,634	)

For Nine Months Ended September 30, 2023

		Common Stock			Additional
		Number of Shares			Amount			Paid-in Capital			Accumulated Deficit			Stockholders' Equity
Balance at December 31, 2022			11,346,535			$	11,346			$	4,320,385			$	(4,471,281	)		$	(139,550	)
Share-based compensation			-				-				58,735				-				58,735
Net loss			-				-				-				(1,804,622	)			(1,804,622	)
Balance at September 30, 2023			11,346,535			$	11,346			$	4,379,120			$	(6,275,903	)		$	(1,885,437	)

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

ACCUSTEM SCIENCES INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

		For the Year Nine Months Ended September 30
		2024			2023
Operating Activities
Net loss		$	(1,133,001	)		$	(1,804,622	)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities
Depreciation			2,723				2,723
Share-based compensation			50,947				58,735
Change in operating assets and liabilities:			-				-
Related party receivable			-				-
Prepaid expenses			145,869				269,880
Other current assets			-				29,603
Accounts payable			211,863				120,529
Related party payable			49,499				49,500
Accrued expenses			7,620				(46,960	)
Net cash used in operating activities			(664,480	)			(1,320,612	)
Investing Activities
Purchases of equipment			-				-
Net cash used in investing activities			-				-
Financing Activities
Advances from related party			781,077				940,665
Payments on note payable			(100,998	)			(283,021	)
Net cash provided by financing activities			680,079				657,644
(Decrease) Increase in cash			15,599				(662,968	)
Cash, beginning of period			21,481				733,978
Cash, end of period		$	37,080			$	71,010
Supplemental disclosure of noncash investing and financing activities
Issuance of Note Payable for payment of prepaid expense			102,915				372,879
Amendment of Issuance of Note Payable for payment of prepaid expense			-				(89,818	)
Supplemental cash flow information
Cash paid for interest		$	2,560			$	4,278

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

ACCUSTEM SCIENCES INC. AND SUBSIDIARIES

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

1. DESCRIPTION OF BUSINESS

AccuStem Sciences, Inc. is an early-stage life sciences company committed to developing and commercializing novel products for the treatment and management of many cancers. The principal activities of the Company are that of a genomics-based personalized medicine business, particularly focused on breast and lung cancer patients.

Liquidity and Going Concern

The condensed consolidated financial statements have been prepared on the going concern basis, which contemplates the realization of assets and discharge of liabilities in the normal course of business. The Company has financed its activities principally from support from a related party. The Company has incurred a net loss in every fiscal period since inception. For the nine months ended September 30, 2024, the Company incurred a net loss of $1,133,001. The Company has an accumulated deficit of $7,654,946as of September 30, 2024. The Company anticipates operating losses to continue for the foreseeable future due to, among other things, costs related to research funding, further development of its technology and products, and expenses related to the commercialization of its products.

Management believes that the Company does not have sufficient cash and current assets to support its operations through at least 12 months from the issuance date of these condensed consolidated financial statements and will require significant additional cash resources to continue its planned research and development activities.

The Company will need additional funds for promoting new products and working capital required to support research and development activities and generate sales from its products. There can be no assurance, however, that such financing will be available when needed, if at all, or on favorable terms and conditions. The precise amount and timing of the funding needs cannot be determined accurately at this time, and will depend on a number of factors, including the quality of product development efforts, management of working capital, and the continuation of normal payment terms and conditions for purchase of services.

In order to address its capital needs, including its planned research and development activities and other expenditures, the Company is actively pursuing additional equity financing in the form of a private investment and public equity. The Company has been in ongoing discussions with institutional investors and other parties with respect to such possible offerings. Adequate financing opportunities might not be available to the Company, when and if needed, on acceptable terms or at all. If the Company is unable to obtain additional financing in sufficient amounts or on acceptable terms or if the Company fails to consummate the private placement or a public offering, the Company will be forced to delay, reduce or eliminate some or all of its research and development programs and product portfolio expansion, which could adversely affect its operating results or business prospects. Although management continues to pursue these plans, there is no assurance that the Company will be successful in obtaining sufficient funding in terms acceptable to the Company to fund continuing operations, if at all. After considering the uncertainties, management determined it is appropriate to continue to adopt the going concern basis in preparing the condensed consolidated financial statements.

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

The principal accounting policies applied in the preparation of these condensed consolidated financial statements are set out below.

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. Generally Accepted Accounting Principles ("U.S. GAAP") and applicable rules and regulations of the U.S. Securities and Exchange Commission ("SEC") regarding interim financial reporting. Certain information and note disclosures normally included in financial statements prepared in accordance with U.S. GAAP have been condensed or omitted pursuant to such rules and regulations. Therefore, these condensed consolidated financial statements should be read in conjunction with the consolidated financial statements and notes included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2023, as filed with the SEC on March 22, 2024. Unless otherwise indicated, all references to "$" are to U.S. dollars, and all references to "£" or "GBP" are to Great Britain Pounds. The Company's reporting currency is U.S. dollars.

Basis of Consolidation

The condensed consolidated financial statements include the accounts of the Company and its wholly-owned subsidiary after elimination of intercompany transactions and balances.

Use of Estimates

The preparation of financial statements in conformity with GAAP requires management of the Company to make estimates and assumptions that affect the reported amounts of assets and liabilities at the date of the financial statements and the reported amounts of income and expenses during the reporting period. Actual results could differ from those estimates.

Risk and Uncertainties

The Company is subject to a number of risks similar to those of other companies of similar size in its industry, including but not limited to, the success of its exploration to research and development activities, need for additional capital (or financing) to fund operating losses, competition from substitute products and services from larger companies, protection of proprietary technology, patent litigation, dependence on key individuals, and risks associated with changes in information technology.

Cash

The Company considers all highly liquid investments purchased with an original maturity date of three months or less at the date of purchase and money market accounts to be cash equivalents. At September 30, 2024 and December 31, 2023, the Company had nocash equivalents and all cash amounts consisted of cash on deposit.

Concentrations of Credit Risk

Financial instruments that potentially subject the Company to significant contribution of credit risk consist of cash. Periodically, the Company maintains deposits in financial institutions in excess of government insured limits. Management believes that the Company is not exposed to significant credit risk as the Company's deposits are held at financial institutions that management believes to be of high credit quality and the Company has not experienced any losses in these deposits.

Equipment, net

Equipment is stated at cost, less accumulated depreciation. The Company depreciates its equipment for financial reporting purposes using the straight-line method over the estimated useful lives of the assets. The Equipment consists of computer equipment, which has a useful life of 3years. Maintenance and repairs are expensed when incurred. Additions and improvements that extend the economic useful life of the asset are capitalized and depreciated over the remaining useful lives of the assets. The cost and accumulated depreciation of assets sold or retired are removed from the respective accounts, and any resulting gain or loss is reflected in current earnings.

Share-based Compensation

The Company may award stock options, performance-based options and other equity-based instruments to its employees, directors and consultants. Compensation cost related to equity-based instruments is based on the fair value of the instrument on the grant date, and is recognized over the requisite service period on a straight-line basis over the vesting period except for performance-based options. Performance-based stock options vest based on the achievement of performance targets. Compensation costs associated with performance-based option awards are recognized over the requisite service period based on probability of achievement. Performance-based stock options require management to make assumptions regarding the likelihood of achieving performance targets.

The Company estimates the fair value of service based and performance-based stock option awards, including modifications of stock option awards, using the Black-Scholes option pricing model. This model derives the fair value of stock options based on certain assumptions related to expected stock price volatility, expected option life, risk-free interest rate and dividend yield.

Recent Accounting Standards

Adopted Accounting Standards

None

Standards not yet adopted

None

3. EQUIPMENT

Equipment consists of the following:

		September 30, 2024			December 31, 2023
Computer equipment		$	10,999				10,999
Less: Accumulated depreciation			9,674				6,951
Equipment, net		$	1,325				4,048

Depreciation expense was approximately $907and $907, respectively, for the three months ended September 30, 2024 and 2023, respectively. For the nine months ended September 30, 2024 and 2023, respectively, depreciation expense was approximately $2,723and $2,723, respectively.

Depreciation expense is included within General and Administrative expenses in the accompanying Condensed Consolidated Statement of Operations.

4. ACCRUED EXPENSES

Accrued expenses consist of the following:

		September 30, 2024			December 31, 2023
Corporate bonus		$	-				-
Legal expense			146,594				146,594
Other			17,459				9,840
Total accrued expenses		$	164,053			$	156,434

5. NOTE PAYABLE

On May 20, 2024, the Company entered into a one-year Directors and Officers Liability Insurance agreement for $102,915. Under the terms of the agreement, the Company made a down payment of $21,000, with the remaining balance financed over the following ten months at an annual percentage rate of 7.99%. Beginning September 2024, the Company will make 10 monthly paymentsof $8,494, with the last payment expected to be made in March 2025. At the end of September 30, 2024, the outstanding balance on the note payable was $57,597.

6. LICENSE

On November 9, 2022, AccuStem and the IEO/University of Milan amended the License to clarify the regulatory path and timeline for the commercialization of StemPrintER. Specifically, the regulatory requirement language has been modified to (i) extend the timeline for regulatory approval or clearance of a licensed product to 36months from the date of the amendment, (ii) clarify that contractual regulatory requirements can be satisfied by the approval or clearance of the test as a Laboratory Developed Test (i.e., approval or clearance can be achieved via the CLIA regulatory path rather than the FDA) and (iii) the timeline for commercial launch has been extended for an additional 60months from the date of the amendment. The amendment provides for a separate licensing payment of $175,000to the IEO.

In addition, for the term of the license, the following milestone payments are required to be made (converted from EUROS to USD using exchange rate of €1:$1.076247)

	●	€50,000($53,812) within 30 days of completion of development of a commercial test;
	●	€100,000($107,625) within 30 days of the first commercial sale of a licensed product; and
	●	€150,000($161,437) within 30 days of first regulatory approval in the U.S. or any other major market.

The License may be terminated by either party in the event of a material breach and in addition, we may terminate the License at any time upon 30 days' notice.

For the three and nine months ended September 30, 2024 and 2023, the Company did not recognize any expense related to this license agreement.

7. LOSS PER SHARE

Basic and diluted net loss per common share were the same since the inclusion of common shares issuable pursuant to the exercise of options in the calculation of diluted net loss per common shares would have been antidilutive.

For the three and nine months ended September 30, 2024 and 2023, loss per share of the Company are as follows:

		Three Months Ended September 30			Nine Months Ended September 30
		2024			2023			2024			2023
Numerator:
Net Loss		$	(328,174	)		$	(598,525	)		$	(1,133,001	)		$	(1,804,622	)
Net loss per share attributable to common stockholders		$	(328,174	)		$	(598,525	)		$	(1,133,001	)		$	(1,804,622	)
Denominator:
Weighted average common shares outstanding, basic and diluted			11,346,535				11,346,535				11,346,535				11,346,535
Net loss per share attributable to common stockholders, basic and diluted		$	(0.03	)		$	(0.05	)		$	(0.10	)		$	(0.16	)

The Company's potentially dilutive securities, which include stock options and warrants, have been excluded from the computation of diluted net loss per common share as the effect would be to reduce the net loss per share. Therefore, the weighted-average number of common shares outstanding used to calculate both basic and diluted net loss per share attributable to common shareholders is the same.

The Company excluded the following from the computation of diluted net loss per share attributable to common stockholders for the three months and nine months ended September 30, 2024 and 2023 because including them would have had an anti-dilutive effect.

		Three Months Ended September 30			Nine Months Ended September 30
		2024			2023			2024			2023
Shares issuable upon exercise of stock options			286,086				1,261,115				286,086				1,261,115
Warrants to purchase common stock outstanding			350,000				350,000				350,000				350,000
Total			636,086				1,611,115				636,086				1,611,115

8. SHARE-BASED COMPENSATION

In August 2021, AccuStem adopted the 2021 Omnibus Equity Incentive Plan (the "Incentive Plan"). The Incentive Plan provides that the Company may grant Options, Stock Appreciation Rights, Restricted Stock, Restricted Stock Units, and Other Share-Based Awards to selected employees, directors, and independent contractors of the Company.

Each Award shall be exercisable at such time or times and subject to such terms and conditions set forth in the Incentive Plan, as shall be determined by the administrator in the applicable award agreement. Total shares authorized by the Incentive Plan was 2,500,000. Awards under the Incentive Plan are exercisable for up to 10years from the date of issuance. There are 1,130,452remaining available shares to be issued under the Incentive Plan at September 30, 2024. The number of shares of Common Stock that are reserved and available for issuance under the Incentive Plan shall be subject to an annual increase on the first day of each calendar year beginning with the first January 1 following the effective date and ending with the last January 1 during the initial ten-year term of the Plan as defined in Section 4(a) of the Incentive Plan.

Options

There were nooptions granted or modified for the three months ended September 30, 2024, and for the three months ended September 30, 2023.

The Company issued 201,000options during the first quarter of 2024 for employees, directors and non-employees under the Incentive Plan. The options granted had an exercise price of $0.49and expire on the ten-year anniversary of the grant date.

For the nine months ended September 30, 2023, stock option activity for time-based options of the Company are as follows:

		Number of Time-Based Share Options			Weighted Average Exercise Price			Weighted Average Remaining Contractual Life (in years)			Aggregate Intrinsic Value
Outstanding at January 1, 2023			416,115			$	1.86				9.13			$	57,207
Issued			-				-				-				-
Exercised			-				-				-				-
Expired/Forfeited			(49,500	)			2.13				-				-
Outstanding at September 30, 2023			366,615			$	1.82				8.40			$	27,384
Vested and exercisable September 30, 2023			119,765			$	1.29				8.22			$	27,384

For the nine months ended September 30, 2023, stock option activity for performance-based options of the Company are as follows:

		Number of Performance- Based Share Options			Weighted Average Exercise Price			Weighted Average Remaining Contractual Life (in years)			Aggregate Intrinsic Value
Outstanding at January 1, 2023			944,000			$	1.45				9.11			$	174,000
Issued			-				-				-				-
Exercised			-				-				-				-
Expired/Forfeited			(49,500	)			-				-				-
Outstanding at September 30, 2023			894,500			$	1.41				8.36			$	-
Vested and exercisable September 30, 2023			-				-				-				-

The aggregate intrinsic value is calculated as the difference between the estimated fair value of the underlying common stock as of September 30, 2024 and the option exercise price.

Total share-based compensation was approximately $118,846and $19,900, respectively, for the three months ended September 30, 2024 and 2023, respectively. For the nine months ended September 30, 2024 and 2023, respectively, share-based compensation was approximately $50,947and $58,735, respectively.

Total share-based compensation expense is included in General and Administrative expenses on the Condensed Consolidated Statement of Operations.

The Company uses the Black-Scholes option pricing model to estimate the fair value of the option awards. The table below summarizes the resulting weighted average inputs used to calculate the estimated fair value of options awarded for the nine months ended September 30, 2024.

		Nine Months Ended September 30, 2024			Nine Months Ended September 30, 2023
Risk-free interest rate			1.80	%			1.54-2.34	%
Expected dividend yield			-				-	%
Expected term			5years

			5- 8.5years
Expected volatility			53.43	%			57.2- 65.7	%

The risk-free interest rate assumption is determined using the yield currently available on U.S. Treasury zero- coupon issues with a remaining term commensurate with the expected term of the award. The Company has historically been a private company and lacks company-specific historical and implied volatility information. Management has estimated expected volatility based on similar public companies. Expected life of the option represents the period of time options are expected to be outstanding. The estimate for dividend yield is 0% because the Company has not historically paid, and does not intend to pay, a dividend on common stock in the foreseeable future.

As of September 30, 2024, there was $790,586unrecognized compensation expense related to options. $97,247of this cost is subject to time-based conditions, and is to be recognized over a period of approximately 2.8years. The remaining $693,338of unrecognized compensation expense relates to performance-based conditions for unvested options. These costs are expected to be recognized over the required service period once the performance condition has occurred or becomes probable. Compensation costs related to the performance stock options are evaluated at each reporting period and subsequently adjusted for changes in the expected outcomes of the performance conditions.

Warrants

In March 2022, the Company issued 350,000common stock warrants to a non-employee under the Incentive Plan. The common stock warrants are subject to vesting and, grantees become fully vested and exercisable when certain performance requirements are met.

The common stock warrants granted have an exercise price of $1.06. The common stock warrants expire on the ten-year anniversary of the grant date. There were nowarrants issued during the three months ended September 30, 2024 and 2023.

For the nine months ended September 30, 2023, warrant activity of the Company are as follows:

		Number of shares			Weighted Average Exercise Price			Weighted average remaining contractual life (in years)			Aggregate Intrinsic Value
Outstanding at January 1, 2023			350,000			$	1.06				9.07			$	-
Issued			-				-				-				-
Exercised			-				-				-				-
Expired/Forfeited			-				-				-				-
Outstanding at September 30, 2023			350,000			$	1.06				8.57			$	122,500
Vested and exercisable September 30, 2023			-				-				-				-

For the nine months ended September 30, 2024, warrant activity of the Company are as follows:

		Number of shares			Weighted Average Exercise Price			Weighted average remaining contractual life (in years)			Aggregate Intrinsic Value
Outstanding at January 1, 2024			350,000			$	1.06				8.07			$	-
Issued			-				-				-				-
Exercised			-				-				-				-
Expired/Forfeited			-				-				-				-
Outstanding at September 30, 2024			350,000			$	1.06				7.57			$	122,500
Vested and exercisable September 30, 2024			-				-				-				-

The grant date fair value for these warrants of $0.66per warrant for a total fair value of $232,490.

There was noshare-based compensation expense recognized during the three and nine months ended September 30, 2024 and 2023 for warrants.

As of September 30, 2024, there were $232,490of total performance-based unrecognized compensation costs related to unvested common stock warrants. These costs are expected to be recognized once the performance condition has occurred or becomes probable.

9. RELATED PARTY TRANSACTIONS

Tiziana Life Sciences Limited ("Tiziana") is a related party as it is under common control. The Company and Tiziana share directors, officers and significant shareholders. The Company has also been formed due to an acquisition of a subsidiary company from Tiziana. As of September 30, 2024, Tiziana owns approximately 11.8% of the Company.

Effective with the demerger agreement, the Company entered into a shared services agreement, where the Company outsources certain limited management and administrative services. The Company notes that the fees consist of payroll costs associated with time spent providing services for the Company and are based on actual time spent and the allocated payroll costs. In addition, the Company is charged, at cost, for utilization of certain office space. There was no mark-up associated with fees charged for these services. For the three months ended September 30, 2024 and 2023, the Company has incurred approximately $2,586and $4,955, respectively.

As of September 30, 2024 and December 31, 2023, $2,104,062and $1,322,986respectively, was also due to Tiziana, as Tiziana had paid for expenses on behalf of the Company. Subsequent to September 30, 2024, Tiziana had paid for an additional $70,097of expenses on behalf of the Company.

In January 2022, the Company and Gabriele Cerrone, who is the Chairman of the Board of Directors and the largest shareholder, entered into an agreement in which he will provide consulting services to the Company for a monthly fee of $5,500. As of September 30, 2024, $181,500was due to Gabriele Cerrone.

10. INCOME TAXES

The Company recorded no provision or benefit for income tax expense for the three months ended September 30, 2024. For all periods presented, the pretax losses incurred by the Company received no corresponding tax benefit because the Company concluded that it is more likely than not that the Company will be unable to realize the value of any resulting deferred tax assets. The Company will continue to assess its position in future periods to determine if it is appropriate to reduce a portion of its valuation allowance in the future.

The Company has no open tax audits with any taxing authority as of September 30, 2024.

11. SUBSEQUENT EVENTS

The Company has evaluated subsequent events for recognition and disclosure through November 18, 2024, which is the date the financial statements were available to be issued. No other matters were identified affecting the accompanying financial statement and related disclosures.

Item 2: Management's Discussion and Analysis of Financial Condition and Results of Operations

You should read the following discussion of our financial condition and results of operations in conjunction with the condensed consolidated financial statements and the related notes included elsewhere in this Form 10-Q and with our audited consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2023, as filed with the SEC on March 22, 2024. In addition to our historical condensed consolidated financial information, the following contains forward-looking statements that reflect our plans, estimates, and beliefs. Our actual results could differ materially from those discussed in the forward-looking statements. Factors that could cause or contribute to these differences include those discussed below and elsewhere in this Form 10-Q.

Forward-Looking Statements

This Quarterly Report on Form 10-Q (this "Form 10-Q") contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, that are intended to be covered by the "safe harbor" created by those sections. Forward-looking statements, which are based on certain assumptions and describe our future plans, strategies and expectations, can generally be identified by the use of forward-looking terms such as "believe," "expect," "may," "will," "should," "would," "could," "seek," "intend," "plan," "goal," "project," "estimate," "anticipate," "strategy," "future," "likely" or the negative thereof or other variations thereon or other comparable terminology. All statements other than statements of historical facts included in this Form 10-Q regarding our strategies, prospects, financial condition, operations, costs, plans and objectives are forward-looking statements. Examples of forward-looking statements include, but are not limited to, statements we make regarding: expectations for revenues, cash flows and financial performance and the anticipated results of our ongoing development and business strategies.

Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, but are not limited to, the following:

	●	the success, cost and timing of our clinical development of our products, including the progress of, and results from, our preclinical and
	●	clinical trials of StemPrintER products, our discovery programs and other potential product candidates;
	●	our ability to obtain and maintain regulatory approval of our product candidates, and any related restrictions, limitations or warnings in the label of any of our product candidates, if approved;
	●	our ability to compete with companies currently marketing or engaged in the development of treatments for indications that our product candidates are designed to target;
	●	our plans to pursue research and development of other future product candidates;
	●	the potential advantages of our product candidates and those being developed;
	●	the rate and degree of market acceptance and clinical utility of our product candidates;
	●	the success of our collaborations and partnerships with third parties;
	●	our estimates regarding the potential market opportunity for our product candidates;
	●	our sales, marketing and distribution capabilities and strategy;
	●	our ability to establish and maintain arrangements for manufacture of our product candidates;
	●	our intellectual property position;
	●	our expectations related to the use of capital;
	●	the effect of the COVID-19 pandemic, including mitigation efforts and economic effects, on any of the foregoing or other aspects of our business operations, including but not limited to our preclinical studies and future clinical trials;
	●	our estimates regarding expenses, future revenues, capital requirements and needs for additional financing;
	●	the impact of government laws and regulations; and
	●	our competitive position.

The forward-looking statements are based upon management's beliefs and assumptions and are made as of the date of this report. We undertake no obligation to publicly update or revise any forward-looking statements included in this report. You should not place undue reliance on these forward-looking statements.

This report also contains or may contain estimates, projections and other information concerning our industry and our business, including data regarding the estimated size of our markets and their projected growth rates. Information that is based on estimates, forecasts, projections, or similar methodologies is inherently subject to uncertainties and actual events or circumstances may differ materially from events and circumstances reflected in this information. Unless otherwise expressly stated, we obtained these industry, business, market and other data from reports, studies and similar data prepared by third parties, industry and general publications, government data and similar sources. In some cases, we do not expressly refer to the sources from which these data are derived.

Unless otherwise stated or the context otherwise requires, the terms "AccuStem" "we," "us," "our" and the "Company" refer collectively to AccuStem and, where appropriate, its subsidiaries.

Overview

We are a clinical stage diagnostics company dedicated to improving quality of life and outcomes for the more than 18 million people worldwide who are diagnosed with cancer each year. Our plan is to develop and commercialize a suite of novel genomic tests that support decision making along the entire continuum of oncology care. Our focus will be the commercialization of our proprietary genomic test, StemPrintER, for patients with early-stage breast cancer, and we estimate this market opportunity represents more than $1.3 billion in annual revenue.

Our primary product candidate is StemPrintER, a 20-gene prognostic assay intended to predict the risk of distant recurrence ("DR") in luminal (ER+/HER2-negative) breast cancer patients. The assay was developed to measure the "stemness" of tumors, or how much a tumor behaves like stem cells which could indicate how likely a cancer is to recur or be resistant to standard treatments, ultimately impacting how patients are managed by their multi-disciplinary care team. StemPrintER has been validated in several clinical cohorts and studies, the largest of which are a consecutive series of approximately 2,400 patients from the European Institute of Oncology ("IEO") and approximately 800 patients from the TransATAC study. In the IEO cohort, StemPrintER High Risk patients ("SPRS High") were 1.85 times more likely to have a distant recurrence compared to Low Risk ("SPRS Low") patients (Figure 1) and in the TransATAC cohort, SPRS High patients were 4.27 times more likely to experience a distant recurrence compared to SPRS Low Risk patients (Figure 2). Together, these data confirm that StemPrintER is highly prognostic for outcomes in patients with breast cancer and indicate the potential utility of the test in the oncology clinic.

*SPRS- StemPrintER Recurrence Score; SPRS High- StemPrintER High Risk; SPRS Low- StemPrintER Low Risk

Beyond our initial plans for StemPrintER, we believe there is significant opportunity to expand our product portfolio. First, given the broad applicability of tumor "stemness", which has been evaluated in a multitude of different cancers, we believe the StemPrint platform will have meaningful clinical utility beyond breast cancer. As such, we will seek to validate and commercialize StemPrint for a variety of different tumor types. Each tumor type, where applicable, would also include ancillary testing to boost our value proposition to physicians and their patients. In addition, we plan to offer ancillary commodity testing (e.g., hereditary genetic testing, somatic mutation testing) that augments our proprietary assays and provides additional information and value to patients and physicians throughout the patient care continuum.

In order to successfully launch StemPrintER, we anticipated needing to achieve several milestones- identifying or building a laboratory to run the test, successfully completing technology transfer from the original laboratory, obtaining CLIA certification for performing the test and performing additional clinical utility research. We have achieved the first milestone by partnering with a commercial laboratory, EmeritusDx, located in Lake Forest, CA,. that will be responsible for processing, testing and reporting StemPrintER results. The work necessary to achieve the second milestone, technology transfer, is actively underway with EmeritusDx. We believe this partnership will also expedite achievement of the third milestone- CLIA certification-as their laboratory already has a high complexity CLIA license. This will enable us to not only report results for clinical use but alsoseek reimbursement from the Centers for Medicare and Medicaid Services. Upon completion of these milestones, we plan to initially launch StemPrintER in the US and then expand to other markets as we evaluate clinical need and revenue opportunity.

Financial Operations Overview

We have no products approved for commercial sale and have not generated revenue to date. We have never been profitable and have incurred net losses in each year since inception. We incurred net losses of $328,174 and $598,525 for the three months ended September 30, 2024 and 2023, respectively. We incurred net losses of $1,133,001 and $1,804,644 for the nine months ended September 30, 2024 and 2023, respectively. As of September 30, 2024, we had an accumulated deficit of $7,326,772. Substantially all of our net losses resulted from expenses incurred in connection with our research and development programs and from general and administrative costs associated with our operations.

Segment Information

As of September 30, 2024, we viewed our operations and managed our business as one operating segment consistent with how our chief operating decision maker, our Chief Executive Officer, makes decisions regarding resource allocation and assessing performance. As of September 30, 2024, substantially all of our assets were located in the United States. Our headquarters and operations are located in New York, NY and London, UK.

Results of Operations

The following discussion and analysis of our results of operations includes a comparison of the three and nine months ended September 30, 2024 to the three and nine months ended September 30, 2023:

		Three Months Ended September 30									Nine Months Ended September 30
		2024			2023			$ Change			% Change			2024			2023			$ Change			% Change
Research and development expenses		$	31,409			$	19,951			$	11,458				57	%		$	96,352			$	50,128			$	46,224				92	%
General and administrative expenses			296,765				578,574				(281,809	)			-49	%			1,036,649				1,754,494				(717,845	)			-41	%
Loss from operations			328,174				598,525				(270,351	)			-45	%			1,133,001				1,804,622				(671,621	)			-37	%
Loss, before income tax			(328,174	)			(598,525	)			270,351				45	%			(1,133,001	)			(1,804,622	)			671,621				-37	%
Income tax benefit (expense)			-				-									%			-				-									%
Net Loss		$	(328,174	)		$	(598,525	)		$	270,351				45	%		$	(1,133,001	)		$	(1,804,622	)		$	671,621				-37	%

Research and development

Research and development expenses for the three and nine months ended September 30, 2024 increased to $31,409 and $96,352, respectively, compared to $19,951 and $50,128, respectively, for the three and nine months ended September 30, 2023 primarily due to an increase in patent related expenses, and laboratory work and consulting.

General and administrative

General and administrative expenses for the three and nine months ended September 30, 2024 decreased to $296,765 and $1,036,649, respectively, compared to $578,574 and $1,754,494, respectively, for the three and nine months ended September 30, 2023 primarily due to a decrease of payroll related costs as a result of decreased headcount and cost saving measures, legal fees, insurance expenses and other compliance expenses.

Liquidity and Capital Resources

Sources of Liquidity

Since our inception, we have not generated any revenue and have incurred significant operating losses. Our potential products are at various phases of development. We do not expect to generate significant revenue from product sales for several years, if at all. Pursuant to the demerger, Tiziana transferred $1,353,373 (£1,000,000) in cash in January 2022 to us. In addition, subject to the terms of the supplemental demerger agreement, Tiziana invested $2,675,940 (£2,000,000) in cash in March 2022 for additional shares of the Company. Our cash flows may fluctuate and are difficult to forecast and will depend on many factors. As of September 30, 2024, our cash balance is $46,072, which is not adequate for our current planned level of operations through at least 12 months from the issuance date of these condensed consolidated financial statements.

Cash Flows

The following table summarizes our cash flows:

		Nine Months Ended September 30,
		2024			2023
Cash flows used in operating activities		$	(664,480	)		$	(1,320,612	)
Cash flows used in investing activities			-				-
Cash flows provided by financing activities			680,079				657,644
Net (decrease) increase in cash and cash equivalents			15,599				(662,968	)
Cash and cash equivalents at beginning of period			21,481				733,978
Cash and cash equivalents at end of period		$	37,080			$	71,010

Operating Activities

During the nine months ended September 30, 2024, net cash used in operating activities was primarily the result of net losses, partially offset by prepaid expenses, an increase in accounts payable, share based compensation and accrued expenses.

Investing Activities

There were no cash flows from investing activities during the three months ended September 30, 2024 or September 30, 2023.

Financing Activities

During the three months ended September 30, 2024, and September 30, 2023, net cash provided by financing activities was primarily due to advances from a related party, partially offset by payments on a note payable.

Market Capital Expenditure Commitments

We have no material commitment for capital expenditures.

Funding Requirements

We expect that our expenses will increase and operating losses will be generated, and we have $7,654,946 of accumulated deficit as at September 30, 2024. Based on our current plans, we believe our existing cash and cash equivalents will not be sufficient to fund our operations and capital expenditure requirements through at least 12 months from the issuance date of these condensed consolidated financial statements. We expect to incur substantial additional expenditures in the near term to support our acceleration of activities. We expect to incur net losses for the foreseeable future. Our ability to fund our product development and clinical operations as well as commercialization of our product candidates, will depend on the amount and timing of cash received from planned financings. Our future capital requirements will depend on many factors, including:

	●	the costs, timing and outcomes of clinical trials and regulatory reviews associated with our product candidates;
	●	the costs of commercialization activities, including product marketing, sales and distribution;
	●	the costs of preparing, filing and prosecuting patent applications and maintaining, enforcing and defending intellectual property-related claims;
	●	the emergence of competing technologies and products and other adverse marketing developments;
	●	the effect on our product development activities of actions taken by the FDA, EMA or other regulatory authorities;
	●	our degree of success in commercializing our product candidates, if and when approved; and
	●	the number and types of future products we develop and commercialize.

A change in the outcome of any of these or other variables with respect to the development of any of our product candidates could significantly change the costs and timing associated with the development of that product candidate. Further, our operating plans may change in the future, and we may need additional funds to meet operational needs and capital requirements associated with such operating plans.

Until such time, if ever, as we can generate substantial product revenue, we expect to finance our operations through a combination of equity financings, debt financings, collaborations with other companies or other strategic transactions. We do not currently have any committed external source of funds. To the extent that we raise additional capital through the sale of equity or convertible debt securities, your ownership interest will be diluted, and the terms of these securities may include liquidation or other preferences that adversely affect your rights as a common stockholder. Debt financing and preferred equity financing, if available, may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making acquisitions or capital expenditures or declaring dividends. If we raise additional funds through collaborations, strategic alliances or marketing, distribution or licensing arrangements with third parties, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs or product candidates or grant licenses on terms that may not be favorable to us. If we are unable to raise additional funds through equity or debt financings or other arrangements when needed, we may be required to delay, limit, reduce or terminate our research, product development or future commercialization efforts or grant rights to develop and market product candidates that we would otherwise prefer to develop and market ourselves.

Further, our operating plans may change, and we may need additional funds to meet operational needs and capital requirements for clinical trials and other research and development activities. We currently have no credit facility or committed sources of capital. Because of the numerous risks and uncertainties associated with the development and commercialization of our product candidates, we are unable to estimate the amounts of increased capital outlays and operating expenditures associated with our current and anticipated product development programs.

Critical Accounting Policies

There have been no significant changes to our critical accounting policies and estimates from the information provided in Item 7, "Management's Discussion and Analysis of Financial Condition and Results of Operations," included in our Form 10-K for the year ended December 31, 2023.

Off-Balance Sheet Arrangements

We have no other off-balance sheet arrangements that have had, or are reasonably likely to have, a material current or future effect on our consolidated financial statements or changes in financial condition, revenues or expenses, results of operations, liquidity, capital expenditures or capital resources.

Recent Accounting Pronouncements

For information on recent accounting pronouncements, see our condensed consolidated financial statements - Note 2 and the related notes found elsewhere in this quarterly report.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

There have been no significant changes to our quantitative and qualitative disclosures about market risk as discussed in Part II, Item 7A "Quantitative and Qualitative Disclosures About Market Risk," included our Form 10-K for the year ended December 31, 2023.

Item 4. Controls and Procedures

Evaluation of Disclosure Controls and Procedures

Our management, with the participation of our principal executive officer and principal financial officer, evaluated the effectiveness of our "disclosure controls and procedures" (as defined in Exchange Act Rules 13a-15I and 15d-15(e)) as of September 30, 2024, the end of the period covered by this Quarterly Report on Form 10-Q. The term "disclosure controls and procedures" as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act, means controls and other procedures of a company that are designed to ensure that information required to be disclosed by a company in the reports that it files under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC's rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by a company in the reports that it files under the Exchange Act is accumulated and communicated to a company's management, including its principal executive officer and principal financial officer, as appropriate to allow timely decisions regarding required disclosure. In designing and evaluating the disclosure controls and procedures, management recognizes that any controls and procedures, no matter how well designed and operated, cannot provide absolute assurance that the objectives of the controls system are met, and no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, within a company have been detected. Based on the evaluation of our disclosure controls and procedures as of September 30, 2024, our management, with the participation of our principal executive officer and principal financial officer has concluded that, based on such evaluation, as of the end of the period covered by this Quarterly Report on Form 10-Q, our disclosure controls and procedures were not effective due to the material weakness described below.

Material Weaknesses in Internal Controls Over Financial Reporting

A material weakness is a deficiency, or a combination of deficiencies, in internal controls over financial reporting, such that there is a reasonable possibility that a material misstatement of our annual or interim financial statements will not be prevented or detected on a timely basis.

Management has determined that we did not maintain effective internal control over financial reporting as of the period ended September 30, 2024 due to a lack of accounting resources resulting in inadequate monitoring controls and other oversight procedures. Our management has determined that our disclosure controls and procedures and internal controls were ineffective due to weaknesses in our financial closing process, inadequate segregation of duties over authorization, review and recording of transactions, lack of accounting resources, as well as the financial reporting of such transactions.

Management's Plan to Remediate the Material Weakness

Management intends to remediate this item in the following manner:

i. Recruit appropriately skilled accounting resources (the "Remediation Plan")

Accordingly, management has determined that these control deficiencies constitute a material weakness. Management has begun implementing the Remediation Plan described herein and intends to continue working on it through the year ended December 31, 2024.

Changes in Internal Control over Financial Reporting

There have been no changes in our internal control over financial reporting during the quarter ended September 30, 2024 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

PART II - OTHER INFORMATION

Item 1. Legal Proceedings

None.

Item 1A. Risk Factors

There have been no material changes to the risk factors previously disclosed in our Form 10-K for the year ended December 31, 2023

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds

None

Item 3. Defaults Upon Senior Securities

None.

Item 4. Mine Safety Disclosures

Not Applicable.

Item 5. Other Information

None.

Item 6. Exhibits

31.1 Certification by Chief Executive Officer pursuant to Rule 13a-14(a) and Rule 15d-14(a) of the Securities Exchange Act

31.2 Certification by Chief Financial Officer pursuant to Rule 13a-14(a) and Rule 15d-14(a) of the Securities Exchange Act

32.1 Certification by Chief Executive Officer Pursuant to 18 U.S.C. Section 1350, As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

32.2 Certification by Chief Financial Officer Pursuant to 18 U.S.C. Section 1350, As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this Report to be signed on its behalf by the undersigned, thereunto duly authorized on November 18, 2024.

	ACCUSTEM SCIENCES, INC.
	/s/ Keeren Shah
	Keeren Shah
	Chief Financial Officer

In accordance with the Securities Exchange Act of 1934, this Report has been signed below on November 18, 2024 by the following persons on behalf of the Registrant and in the capacities indicated.

/s/ Wendy Blosser
Wendy Blosser
Chief Executive Officer and Director
/s/ Keeren Shah
Keeren Shah
Chief Financial Officer

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