Charles River Laboratories International Inc.

07/03/2024 | News release | Distributed by Public on 07/03/2024 14:13

Empower Your Gene Therapy Research and Ignite the Path to Development Breakthroughs

Off-the-shelf Plasmids and Viral Vector Products

AAV Reference Materials: As a critical component for comparison between studies and clinical trials, our pre-made AAV products are purified and come ready to use for both in vitro and in vivo studies. As a leader in AAV manufacturing, our product catalog includes both empty and full capsids.

We've also partnered with the Michael J. Fox Foundation to provide AAV tools for studying Parkinson's disease.

LVV Reference Materials: Purified lentivirus reference materials expressing GFP, RFP, mCherry, Luciferase, and Cre are ready for use in in vitro and in vivo animal studies. Alternatively, if you need a custom reference material, our team of scientists will help you design and generate the product that best fits your needs.

AAV and LVV Plasmids: For a process that typically takes several months to complete, having plasmids immediately available for use is a game-changer in the fast-paced industry of gene therapies. Our Research Grade (RG), High Quality (HQ), and GMP plasmids are pre-manufactured and fully documented. These off-the-shelf plasmids save you time and accelerate your gene and cell therapy discovery and development.

Viral Vector Packaging Services

Offering tailored AAV and lentivirus packaging services for every research phase and at multiple scales, our comprehensive testing portfolio prioritizes quality, and includes but is not limited to silver staining, AAV empty/full ratio, endotoxin levels, sterility, and mycoplasma. This ensures you receive stable, pure, high-yield viral vectors, optimizing performance for superior therapeutic results.

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Custom Cloning Services

In the ever-evolving landscape of molecular biology, the need for precise, efficient, and reliable genetic tools has never been greater. Whether you're exploring the intricacies of gene expression, modifying genetic sequences, or aiming to silence specific genes, our cloning services are designed to empower your research. Our specialized offerings include:

Molecular Cloning Services: From designing and constructing custom viral vector to packaging and purifying viral particles, simply provide us your project details and we will deliver ready-to-use viral particles generated according to your exact specifications.

Gene Synthesis and Mutagenesis: We offer gene synthesis services and site-directed mutagenesis services to save you time and generate the construct that meets your exact specifications, creating specific variants or disease-specific mutants.

shRNA Cloning: We also offer multiple shRNA cloning options to help you plan the most time-saving and cost-effective strategy for your gene silencing experiments.

A clear look at the full picture:

  • Comprehensive gene therapy products and services portfolio
  • Premium quality offering leveraging CDMO centers of excellence
  • Supports a seamless transition to clinic and commercial
  • Trusted partnership to empower your gene therapy research

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Gene Therapy Research Solutions
Navigating the complexities of advancing your gene therapy research can be challenging. Leveraging decades of experience and knowledge with Charles River grants you access to fit-for-purpose research solutions for a seamless transition to larger scales and GMP.
Bring your therapies to life